Towards a long-term model construction for the dynamic simulation of HIV infection
This study involves the mathematical modelling of long-term HIV dynamics.The proposed model is able to predict the entire trajectory of the disease:initial viremia in the early weeks of the infection, latency, and progressionto AIDS; a range spanning approximately ten years. The model outcomes were...
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| Format: | Article |
| Language: | English |
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AIMS Press
2007-04-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.489 |
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| author | M. Hadjiandreou Raul Conejeros Vassilis S. Vassiliadis |
| author_facet | M. Hadjiandreou Raul Conejeros Vassilis S. Vassiliadis |
| author_sort | M. Hadjiandreou |
| collection | DOAJ |
| description | This study involves the mathematical modelling of long-term HIV dynamics.The proposed model is able to predict the entire trajectory of the disease:initial viremia in the early weeks of the infection, latency, and progressionto AIDS; a range spanning approximately ten years. The model outcomes were comparedto clinical data and significant agreement was achieved. The formulatedmodel considers all important population compartments including macrophages,latently-infected CD4+ T-cells, and cytotoxic T-lymphocytes (CTLs),an attempt which in many respects is novel in the area of HIV modelling.The ranges of the model parameters and initial conditions were obtainedfrom literature, and their values were determined in this work directlyby fitting published clinical data. Furthermore, the simulation resultsemphasize the importance of macrophages in HIV infection and progressionto AIDS and show a clear correlation between the level of CTLs andHIV progression. The ability of the model to correlate analyticaldata gives credibility to its predictions, a fact that will beexploited in future research in modelling immunological and pharmacologicalavenues of treatment. |
| format | Article |
| id | doaj-art-b3eb1f666257419cb93fc4b1cb615f2c |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2007-04-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-b3eb1f666257419cb93fc4b1cb615f2c2025-01-24T01:53:48ZengAIMS PressMathematical Biosciences and Engineering1551-00182007-04-014348950410.3934/mbe.2007.4.489Towards a long-term model construction for the dynamic simulation of HIV infectionM. Hadjiandreou0Raul Conejeros1Vassilis S. Vassiliadis2Department of Chemical Engineering, University of Cambridge, Pembroke Street, Cambridge, CB2 3RADepartment of Chemical Engineering, University of Cambridge, Pembroke Street, Cambridge, CB2 3RADepartment of Chemical Engineering, University of Cambridge, Pembroke Street, Cambridge, CB2 3RAThis study involves the mathematical modelling of long-term HIV dynamics.The proposed model is able to predict the entire trajectory of the disease:initial viremia in the early weeks of the infection, latency, and progressionto AIDS; a range spanning approximately ten years. The model outcomes were comparedto clinical data and significant agreement was achieved. The formulatedmodel considers all important population compartments including macrophages,latently-infected CD4+ T-cells, and cytotoxic T-lymphocytes (CTLs),an attempt which in many respects is novel in the area of HIV modelling.The ranges of the model parameters and initial conditions were obtainedfrom literature, and their values were determined in this work directlyby fitting published clinical data. Furthermore, the simulation resultsemphasize the importance of macrophages in HIV infection and progressionto AIDS and show a clear correlation between the level of CTLs andHIV progression. The ability of the model to correlate analyticaldata gives credibility to its predictions, a fact that will beexploited in future research in modelling immunological and pharmacologicalavenues of treatment.https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.489macrophagesdynamic simulationlong-term dynamicshiv modellingctls. |
| spellingShingle | M. Hadjiandreou Raul Conejeros Vassilis S. Vassiliadis Towards a long-term model construction for the dynamic simulation of HIV infection Mathematical Biosciences and Engineering macrophages dynamic simulation long-term dynamics hiv modelling ctls. |
| title | Towards a long-term model construction for the dynamic simulation of HIV infection |
| title_full | Towards a long-term model construction for the dynamic simulation of HIV infection |
| title_fullStr | Towards a long-term model construction for the dynamic simulation of HIV infection |
| title_full_unstemmed | Towards a long-term model construction for the dynamic simulation of HIV infection |
| title_short | Towards a long-term model construction for the dynamic simulation of HIV infection |
| title_sort | towards a long term model construction for the dynamic simulation of hiv infection |
| topic | macrophages dynamic simulation long-term dynamics hiv modelling ctls. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.489 |
| work_keys_str_mv | AT mhadjiandreou towardsalongtermmodelconstructionforthedynamicsimulationofhivinfection AT raulconejeros towardsalongtermmodelconstructionforthedynamicsimulationofhivinfection AT vassilissvassiliadis towardsalongtermmodelconstructionforthedynamicsimulationofhivinfection |