What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?
Accurate evaluation of coronary artery pathology is essential for risk stratification and tailoring appropriate treatment. Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque characterization. Since then, several studies have evaluated the ef...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1507892/full |
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| author | Nathan Angelo Lecaros Yap Zahid Khan Zahid Khan Xingwei He Jae-Geun Lee Soe Maung Kimberley R. Morgan Tingquan Zhou Helle Precht Patrick W. Serruys Patrick W. Serruys Hector M. Garcia-Garcia Yoshinobu Onuma Sean Hynes Sebastian Kelle Anthony Mathur Anthony Mathur Andreas Baumbach Andreas Baumbach Christos V. Bourantas Christos V. Bourantas |
| author_facet | Nathan Angelo Lecaros Yap Zahid Khan Zahid Khan Xingwei He Jae-Geun Lee Soe Maung Kimberley R. Morgan Tingquan Zhou Helle Precht Patrick W. Serruys Patrick W. Serruys Hector M. Garcia-Garcia Yoshinobu Onuma Sean Hynes Sebastian Kelle Anthony Mathur Anthony Mathur Andreas Baumbach Andreas Baumbach Christos V. Bourantas Christos V. Bourantas |
| author_sort | Nathan Angelo Lecaros Yap |
| collection | DOAJ |
| description | Accurate evaluation of coronary artery pathology is essential for risk stratification and tailoring appropriate treatment. Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque characterization. Since then, several studies have evaluated the efficacy of the existing intravascular imaging modalities in assessing plaque pathology and composition and their potential in guiding intervention and predicting vulnerable plaques. Today it is known that intravascular imaging is an indispensable tool in percutaneous coronary intervention planning, but the existing modalities have a limited efficacy in predicting lesion vulnerability; a fact that should be attributed to their advantages and limitations in accurately assessing morpho-pathological features that are common in advanced atherosclerotic plaques. This review aims to provide a comprehensive evaluation of the performance of intravascular imaging in characterizing plaque phenotypes using histology as a reference standard; it summarizes the studies comparing the available invasive imaging techniques against histology, discusses the findings and limitations of these studies and highlights the potential of novel intravascular imaging approaches that were introduced for a more complete and comprehensive evaluation of plaque pathobiology. |
| format | Article |
| id | doaj-art-b3d70822bae8406e8689607268a04aa9 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-b3d70822bae8406e8689607268a04aa92025-01-24T07:13:50ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011210.3389/fcvm.2025.15078921507892What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?Nathan Angelo Lecaros Yap0Zahid Khan1Zahid Khan2Xingwei He3Jae-Geun Lee4Soe Maung5Kimberley R. Morgan6Tingquan Zhou7Helle Precht8Patrick W. Serruys9Patrick W. Serruys10Hector M. Garcia-Garcia11Yoshinobu Onuma12Sean Hynes13Sebastian Kelle14Anthony Mathur15Anthony Mathur16Andreas Baumbach17Andreas Baumbach18Christos V. Bourantas19Christos V. Bourantas20Device and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomBarts Heart Centre, Barts Health NHS Trust, London, United KingdomMedical Education, University of South Wales, Wales and University of Buckingham, Buckingham, United KingdomDevice and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomDevice and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomDevice and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomDevice and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomDevice and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomConrad Research Center, Radiography Education, University College Lillebælt, Odense, DenmarkFaculty of Medicine, National Heart & Lung Institute, Imperial College London, United KingdomDepartment of Cardiology, National University of Ireland, Galway, IrelandInterventional Cardiology Department, MedStar Washington Hospital Center, Washington, DC, United StatesDepartment of Cardiology, National University of Ireland, Galway, IrelandDepartment of Pathology, National University of Ireland, Galway, IrelandDepartment of Cardiology, Radiology and Intensive Care Medicine, Deutsches Herzzentrum Der Charite, Berlin, GermanyDevice and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomBarts Heart Centre, Barts Health NHS Trust, London, United KingdomDevice and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomBarts Heart Centre, Barts Health NHS Trust, London, United KingdomDevice and Innovation Centre, William Harvey Research Institute Queen Mary University, London, United KingdomBarts Heart Centre, Barts Health NHS Trust, London, United KingdomAccurate evaluation of coronary artery pathology is essential for risk stratification and tailoring appropriate treatment. Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque characterization. Since then, several studies have evaluated the efficacy of the existing intravascular imaging modalities in assessing plaque pathology and composition and their potential in guiding intervention and predicting vulnerable plaques. Today it is known that intravascular imaging is an indispensable tool in percutaneous coronary intervention planning, but the existing modalities have a limited efficacy in predicting lesion vulnerability; a fact that should be attributed to their advantages and limitations in accurately assessing morpho-pathological features that are common in advanced atherosclerotic plaques. This review aims to provide a comprehensive evaluation of the performance of intravascular imaging in characterizing plaque phenotypes using histology as a reference standard; it summarizes the studies comparing the available invasive imaging techniques against histology, discusses the findings and limitations of these studies and highlights the potential of novel intravascular imaging approaches that were introduced for a more complete and comprehensive evaluation of plaque pathobiology.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1507892/fullintravascular ultrasoundoptical coherence tomographynear-infrared spectroscopyhistologyhybrid intravascular imaging |
| spellingShingle | Nathan Angelo Lecaros Yap Zahid Khan Zahid Khan Xingwei He Jae-Geun Lee Soe Maung Kimberley R. Morgan Tingquan Zhou Helle Precht Patrick W. Serruys Patrick W. Serruys Hector M. Garcia-Garcia Yoshinobu Onuma Sean Hynes Sebastian Kelle Anthony Mathur Anthony Mathur Andreas Baumbach Andreas Baumbach Christos V. Bourantas Christos V. Bourantas What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? Frontiers in Cardiovascular Medicine intravascular ultrasound optical coherence tomography near-infrared spectroscopy histology hybrid intravascular imaging |
| title | What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? |
| title_full | What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? |
| title_fullStr | What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? |
| title_full_unstemmed | What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? |
| title_short | What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? |
| title_sort | what have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition |
| topic | intravascular ultrasound optical coherence tomography near-infrared spectroscopy histology hybrid intravascular imaging |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1507892/full |
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