Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation
The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights int...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/169506 |
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| Summary: | The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR𝛼, 𝛽/𝛿, and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1. |
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| ISSN: | 1687-4757 1687-4765 |