Splenic Complications of Babesia microti Infection in Humans: A Systematic Review
Splenic complications of acute Babesia microti infection include splenomegaly, splenic infarct, and splenic rupture. These complications are relatively rarely reported, and the aim of this research was to synthetize data on this topic according to the Preferred Reporting Items for Systematic Reviews...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2020/6934149 |
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| author | Igor Dumic Cristian Madrid Libardo Rueda Prada Charles W. Nordstrom Pahnwat Tonya Taweesedt Poornima Ramanan |
| author_facet | Igor Dumic Cristian Madrid Libardo Rueda Prada Charles W. Nordstrom Pahnwat Tonya Taweesedt Poornima Ramanan |
| author_sort | Igor Dumic |
| collection | DOAJ |
| description | Splenic complications of acute Babesia microti infection include splenomegaly, splenic infarct, and splenic rupture. These complications are relatively rarely reported, and the aim of this research was to synthetize data on this topic according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using the PubMed database. In this review, we find that unlike other severe complications of babesiosis, splenic infarct and rupture occur in younger and immunocompetent patients, and they do not correlate with parasitemia level. Furthermore, admission hemoglobin of 10 mg/dl or less, platelet count of 50 × 10⁹/L or less, presence of hemodynamic instability, and splenic rupture were associated independently with an increased risk of requiring splenectomy. As babesiosis is an emerging tick-borne zoonosis, we hope that this review will help to raise awareness among clinicians regarding this rare but potentially life-threatening complication. |
| format | Article |
| id | doaj-art-b3bbdac6cb32408f94a5b9d300e0cdc3 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-b3bbdac6cb32408f94a5b9d300e0cdc32025-02-03T01:27:05ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932020-01-01202010.1155/2020/69341496934149Splenic Complications of Babesia microti Infection in Humans: A Systematic ReviewIgor Dumic0Cristian Madrid1Libardo Rueda Prada2Charles W. Nordstrom3Pahnwat Tonya Taweesedt4Poornima Ramanan5Mayo Clinic Alix College of Medicine and Science, Rochester, MN, USADivision of Hospital Medicine, Mayo Clinic Health System, Eau Claire, WI, USADivision of Hospital Medicine, Mayo Clinic Health System, Eau Claire, WI, USAMayo Clinic Alix College of Medicine and Science, Rochester, MN, USAIcahn School of Medicine at Mount Sinai, New York City, NY, USADivision of Infectious Disease, University of Colorado, Denver, CO, USASplenic complications of acute Babesia microti infection include splenomegaly, splenic infarct, and splenic rupture. These complications are relatively rarely reported, and the aim of this research was to synthetize data on this topic according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using the PubMed database. In this review, we find that unlike other severe complications of babesiosis, splenic infarct and rupture occur in younger and immunocompetent patients, and they do not correlate with parasitemia level. Furthermore, admission hemoglobin of 10 mg/dl or less, platelet count of 50 × 10⁹/L or less, presence of hemodynamic instability, and splenic rupture were associated independently with an increased risk of requiring splenectomy. As babesiosis is an emerging tick-borne zoonosis, we hope that this review will help to raise awareness among clinicians regarding this rare but potentially life-threatening complication.http://dx.doi.org/10.1155/2020/6934149 |
| spellingShingle | Igor Dumic Cristian Madrid Libardo Rueda Prada Charles W. Nordstrom Pahnwat Tonya Taweesedt Poornima Ramanan Splenic Complications of Babesia microti Infection in Humans: A Systematic Review Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Splenic Complications of Babesia microti Infection in Humans: A Systematic Review |
| title_full | Splenic Complications of Babesia microti Infection in Humans: A Systematic Review |
| title_fullStr | Splenic Complications of Babesia microti Infection in Humans: A Systematic Review |
| title_full_unstemmed | Splenic Complications of Babesia microti Infection in Humans: A Systematic Review |
| title_short | Splenic Complications of Babesia microti Infection in Humans: A Systematic Review |
| title_sort | splenic complications of babesia microti infection in humans a systematic review |
| url | http://dx.doi.org/10.1155/2020/6934149 |
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