Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context
Summary: Background: Pancreatic adenocarcinoma (PAC) has a poor prognosis and substantially impairs health-related quality of life (HRQoL). Large studies on longitudinal HRQoL in patients with PAC, taking patient treatment into account, are lacking. This study aimed to investigate HRQoL over time i...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537024006473 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591790362853376 |
|---|---|
| author | Anne M. Gehrels Pauline A.J. Vissers Mirjam A.G. Sprangers Nienke M. Fijnheer Esther N. Pijnappel Lydia G. van der Geest Geert A. Cirkel Judith de Vos-Geelen Marjolein Y.V. Homs Geert- Jan Creemers Martijn W.J. Stommel Lois A. Daamen Marc G. Besselink Johanna W. Wilmink Hanneke W.M. van Laarhoven |
| author_facet | Anne M. Gehrels Pauline A.J. Vissers Mirjam A.G. Sprangers Nienke M. Fijnheer Esther N. Pijnappel Lydia G. van der Geest Geert A. Cirkel Judith de Vos-Geelen Marjolein Y.V. Homs Geert- Jan Creemers Martijn W.J. Stommel Lois A. Daamen Marc G. Besselink Johanna W. Wilmink Hanneke W.M. van Laarhoven |
| author_sort | Anne M. Gehrels |
| collection | DOAJ |
| description | Summary: Background: Pancreatic adenocarcinoma (PAC) has a poor prognosis and substantially impairs health-related quality of life (HRQoL). Large studies on longitudinal HRQoL in patients with PAC, taking patient treatment into account, are lacking. This study aimed to investigate HRQoL over time in patients with PAC undergoing various treatments. Methods: This nationwide cohort study included patients diagnosed with PAC between 2015 and 2020. Data were collected from the Dutch Pancreatic Cancer Project (PACAP) and the Netherlands Cancer Registry. Patients were categorized into four groups based on treatment modality: resection (R-PAC), chemotherapy for localized disease (C-PAC), chemotherapy for metastatic disease (M1-C-PAC), and best supportive care (BSC). HRQoL was assessed using the EORTC QLQ-C30 and -PAN26 questionnaires at baseline, during treatment, and at 0–3 months and 3–6 months after treatment. Linear mixed models were used to analyze changes in HRQoL over time, with clinically relevant changes defined as a minimal mean difference of 10 points in absolute scores and reported with 95% confidence intervals. Findings: Overall, 1496 patients were included (673 [45.0%] female), of whom 675 (45.1%) in R-PAC, 319 (21.3%) in C-PAC, 340 patients (22.7%) in M1-C-PAC, and 162 (10.8%) in BSC group. In R-PAC, hepatic symptoms and health care satisfaction improved while role and social functioning deteriorated and eating related problems, side effects and fear of future health increased during treatment. In C-PAC, insomnia, pancreatic pain, hepatic symptoms decreased while diarrhea, side effects and fear of future health increased. In M1-C-PAC, pain, insomnia, pancreatic pain, hepatic symptoms, ascites and constipation decreased, sexuality improved while fear of future health and side effects increased. In BSC, hepatic symptoms decreased and flatulence increased. Interpretation: This nationwide study identified specific improvements and deteriorations in various HRQoL domains during 6 months follow-up. This information may be valuable in the clinical setting to inform patients on potential outcomes of the course of HRQoL during various treatment strategies. Funding: None. |
| format | Article |
| id | doaj-art-b3ae574690c5473f81c5e96a259a551a |
| institution | Kabale University |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj-art-b3ae574690c5473f81c5e96a259a551a2025-01-22T05:43:46ZengElsevierEClinicalMedicine2589-53702025-02-0180103068Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in contextAnne M. Gehrels0Pauline A.J. Vissers1Mirjam A.G. Sprangers2Nienke M. Fijnheer3Esther N. Pijnappel4Lydia G. van der Geest5Geert A. Cirkel6Judith de Vos-Geelen7Marjolein Y.V. Homs8Geert- Jan Creemers9Martijn W.J. Stommel10Lois A. Daamen11Marc G. Besselink12Johanna W. Wilmink13Hanneke W.M. van Laarhoven14Department of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands; Corresponding author. Department of Medical Oncology, Amsterdam UMC, PO Box 22660, Amsterdam, 1100DD, the Netherlands.Department of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the Netherlands; Department of Surgery, RadboudUMC, Nijmegen, the NetherlandsCancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands; Department of Medical Psychology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the NetherlandsDepartment of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the NetherlandsDepartment of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the NetherlandsDepartment of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the NetherlandsDepartment of Medical Oncology, Regional Academic Cancer Center Utrecht, Meander Medical Center Amersfoort, University Medical Center, Utrecht, the NetherlandsDivision of Medical Oncology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the NetherlandsDepartment of Medical Oncology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the NetherlandsDepartment of Medical Oncology, Catharina Hospital, Eindhoven, the NetherlandsDepartment of Surgery, RadboudUMC, Nijmegen, the NetherlandsDepartment of Surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht and St. Antonius Hospital Nieuwegein, the Netherlands; Division of Imaging and Oncology, UMC Utrecht, Utrecht University, Utrecht, the NetherlandsCancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands; Amsterdam UMC Location University of Amsterdam, Department of Surgery, Amsterdam, the NetherlandsDepartment of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the NetherlandsDepartment of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands; Corresponding author. Department of Medical Oncology, Amsterdam UMC, Office D3-312, PO Box 22660, Amsterdam, 1100DD, the Netherlands.Summary: Background: Pancreatic adenocarcinoma (PAC) has a poor prognosis and substantially impairs health-related quality of life (HRQoL). Large studies on longitudinal HRQoL in patients with PAC, taking patient treatment into account, are lacking. This study aimed to investigate HRQoL over time in patients with PAC undergoing various treatments. Methods: This nationwide cohort study included patients diagnosed with PAC between 2015 and 2020. Data were collected from the Dutch Pancreatic Cancer Project (PACAP) and the Netherlands Cancer Registry. Patients were categorized into four groups based on treatment modality: resection (R-PAC), chemotherapy for localized disease (C-PAC), chemotherapy for metastatic disease (M1-C-PAC), and best supportive care (BSC). HRQoL was assessed using the EORTC QLQ-C30 and -PAN26 questionnaires at baseline, during treatment, and at 0–3 months and 3–6 months after treatment. Linear mixed models were used to analyze changes in HRQoL over time, with clinically relevant changes defined as a minimal mean difference of 10 points in absolute scores and reported with 95% confidence intervals. Findings: Overall, 1496 patients were included (673 [45.0%] female), of whom 675 (45.1%) in R-PAC, 319 (21.3%) in C-PAC, 340 patients (22.7%) in M1-C-PAC, and 162 (10.8%) in BSC group. In R-PAC, hepatic symptoms and health care satisfaction improved while role and social functioning deteriorated and eating related problems, side effects and fear of future health increased during treatment. In C-PAC, insomnia, pancreatic pain, hepatic symptoms decreased while diarrhea, side effects and fear of future health increased. In M1-C-PAC, pain, insomnia, pancreatic pain, hepatic symptoms, ascites and constipation decreased, sexuality improved while fear of future health and side effects increased. In BSC, hepatic symptoms decreased and flatulence increased. Interpretation: This nationwide study identified specific improvements and deteriorations in various HRQoL domains during 6 months follow-up. This information may be valuable in the clinical setting to inform patients on potential outcomes of the course of HRQoL during various treatment strategies. Funding: None.http://www.sciencedirect.com/science/article/pii/S2589537024006473Pancreatic cancerPancreatic adenocarcinomaHealth-related quality of lifeTreatment strategies |
| spellingShingle | Anne M. Gehrels Pauline A.J. Vissers Mirjam A.G. Sprangers Nienke M. Fijnheer Esther N. Pijnappel Lydia G. van der Geest Geert A. Cirkel Judith de Vos-Geelen Marjolein Y.V. Homs Geert- Jan Creemers Martijn W.J. Stommel Lois A. Daamen Marc G. Besselink Johanna W. Wilmink Hanneke W.M. van Laarhoven Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context EClinicalMedicine Pancreatic cancer Pancreatic adenocarcinoma Health-related quality of life Treatment strategies |
| title | Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context |
| title_full | Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context |
| title_fullStr | Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context |
| title_full_unstemmed | Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context |
| title_short | Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context |
| title_sort | longitudinal health related quality of life in patients with pancreatic cancer stratified by treatment a nationwide cohort studyresearch in context |
| topic | Pancreatic cancer Pancreatic adenocarcinoma Health-related quality of life Treatment strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2589537024006473 |
| work_keys_str_mv | AT annemgehrels longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT paulineajvissers longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT mirjamagsprangers longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT nienkemfijnheer longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT esthernpijnappel longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT lydiagvandergeest longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT geertacirkel longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT judithdevosgeelen longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT marjoleinyvhoms longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT geertjancreemers longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT martijnwjstommel longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT loisadaamen longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT marcgbesselink longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT johannawwilmink longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext AT hannekewmvanlaarhoven longitudinalhealthrelatedqualityoflifeinpatientswithpancreaticcancerstratifiedbytreatmentanationwidecohortstudyresearchincontext |