Ischemic Colitis During Pegylated Interferon-Alpha and Ribavirin Therapy for Chronic Hepatitis C
Rare cases of ischemic colitis associated with interferon-alpha (IFN-α) treatment for chronic hepatitis C (HCV) infection and metastatic cancer have been reported. The present study describes the first case of ischemic colitis attributable to pegylated IFN-α and ribavirin combination therapy in an H...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2006/687836 |
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| author | Yvette Leung Stefan J Urbanski Lynn Schindel Robert P Myers |
| author_facet | Yvette Leung Stefan J Urbanski Lynn Schindel Robert P Myers |
| author_sort | Yvette Leung |
| collection | DOAJ |
| description | Rare cases of ischemic colitis associated with interferon-alpha (IFN-α) treatment for chronic hepatitis C (HCV) infection and metastatic cancer have been reported. The present study describes the first case of ischemic colitis attributable to pegylated IFN-α and ribavirin combination therapy in an HCV-infected patient after 34 weeks of treatment. The clinical presentation, endoscopic appearance and histopathology of the colon were consistent with ischemic colitis, and the patient’s symptoms rapidly resolved with cessation of therapy. The association between the therapy and the pathogenesis of ischemic colitis is unclear, but immunoregulatory, vasospastic and procoagulant mechanisms have been proposed. Physicians should be aware of this complication, and should consider it in any HCV-infected patient taking pegylated IFN-α and ribavirin who develops abdominal discomfort and gastrointestinal bleeding. |
| format | Article |
| id | doaj-art-b3a7cf16a5b048e2afc88f06f9cfbefd |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-b3a7cf16a5b048e2afc88f06f9cfbefd2025-02-03T05:57:36ZengWileyCanadian Journal of Gastroenterology0835-79002006-01-01201066166310.1155/2006/687836Ischemic Colitis During Pegylated Interferon-Alpha and Ribavirin Therapy for Chronic Hepatitis CYvette Leung0Stefan J Urbanski1Lynn Schindel2Robert P Myers3Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaDepartment of Pathology, University of Calgary, Calgary, Alberta, CanadaLiver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaLiver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaRare cases of ischemic colitis associated with interferon-alpha (IFN-α) treatment for chronic hepatitis C (HCV) infection and metastatic cancer have been reported. The present study describes the first case of ischemic colitis attributable to pegylated IFN-α and ribavirin combination therapy in an HCV-infected patient after 34 weeks of treatment. The clinical presentation, endoscopic appearance and histopathology of the colon were consistent with ischemic colitis, and the patient’s symptoms rapidly resolved with cessation of therapy. The association between the therapy and the pathogenesis of ischemic colitis is unclear, but immunoregulatory, vasospastic and procoagulant mechanisms have been proposed. Physicians should be aware of this complication, and should consider it in any HCV-infected patient taking pegylated IFN-α and ribavirin who develops abdominal discomfort and gastrointestinal bleeding.http://dx.doi.org/10.1155/2006/687836 |
| spellingShingle | Yvette Leung Stefan J Urbanski Lynn Schindel Robert P Myers Ischemic Colitis During Pegylated Interferon-Alpha and Ribavirin Therapy for Chronic Hepatitis C Canadian Journal of Gastroenterology |
| title | Ischemic Colitis During Pegylated Interferon-Alpha and Ribavirin Therapy for Chronic Hepatitis C |
| title_full | Ischemic Colitis During Pegylated Interferon-Alpha and Ribavirin Therapy for Chronic Hepatitis C |
| title_fullStr | Ischemic Colitis During Pegylated Interferon-Alpha and Ribavirin Therapy for Chronic Hepatitis C |
| title_full_unstemmed | Ischemic Colitis During Pegylated Interferon-Alpha and Ribavirin Therapy for Chronic Hepatitis C |
| title_short | Ischemic Colitis During Pegylated Interferon-Alpha and Ribavirin Therapy for Chronic Hepatitis C |
| title_sort | ischemic colitis during pegylated interferon alpha and ribavirin therapy for chronic hepatitis c |
| url | http://dx.doi.org/10.1155/2006/687836 |
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