Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease
Background: Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential tr...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S209012322400047X |
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| author | Jinling Li Ting Luo Dou Wang Yao Zhao Yuanxiang Jin Guiling Yang Xin Zhang |
| author_facet | Jinling Li Ting Luo Dou Wang Yao Zhao Yuanxiang Jin Guiling Yang Xin Zhang |
| author_sort | Jinling Li |
| collection | DOAJ |
| description | Background: Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential treatment of inflammatory bowel disease (IBD) and can, to some extent, compensate for the limitations of existing therapies. Aim of review: This review summarizes the recent advances and potential mechanisms underlying PDEVs obtained from different sources to alleviate IBD. In addition, the review discusses the possible applications and challenges of PDEVs, providing a theoretical basis for exploring novel and practical therapeutic strategies for IBD. Key scientific concepts of review: In IBD, the crosstalk mechanism of PDEVs may regulate the intestinal microenvironment homeostasis, especially immune responses, the intestinal barrier, and the gut microbiota. In addition, drug loading enhances the therapeutic potential of PDEVs, particularly regarding improved tissue targeting and stability. In the future, not only immunotherapy based on PDEVs may be an effective treatment for IBD, but also the intestinal barrier and intestinal microbiota will be a new direction for the treatment of IBD. |
| format | Article |
| id | doaj-art-b3a5dda45d3a44c0a59fc9461daa7fd7 |
| institution | Kabale University |
| issn | 2090-1232 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj-art-b3a5dda45d3a44c0a59fc9461daa7fd72025-01-18T05:04:16ZengElsevierJournal of Advanced Research2090-12322025-02-01686374Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel diseaseJinling Li0Ting Luo1Dou Wang2Yao Zhao3Yuanxiang Jin4Guiling Yang5Xin Zhang6Department of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang Province, China; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, ChinaBiomanufacturing Research Institute of Xianghu Laboratory, Hangzhou 311231, Zhejiang Province, ChinaBiomanufacturing Research Institute of Xianghu Laboratory, Hangzhou 311231, Zhejiang Province, China; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, Zhejiang Province, ChinaState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, China; Biomanufacturing Research Institute of Xianghu Laboratory, Hangzhou 311231, Zhejiang Province, China; Corresponding authors at: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, China (G. Yang).Department of Food Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang Province, China; Corresponding authors at: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang Province, China (G. Yang).Background: Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential treatment of inflammatory bowel disease (IBD) and can, to some extent, compensate for the limitations of existing therapies. Aim of review: This review summarizes the recent advances and potential mechanisms underlying PDEVs obtained from different sources to alleviate IBD. In addition, the review discusses the possible applications and challenges of PDEVs, providing a theoretical basis for exploring novel and practical therapeutic strategies for IBD. Key scientific concepts of review: In IBD, the crosstalk mechanism of PDEVs may regulate the intestinal microenvironment homeostasis, especially immune responses, the intestinal barrier, and the gut microbiota. In addition, drug loading enhances the therapeutic potential of PDEVs, particularly regarding improved tissue targeting and stability. In the future, not only immunotherapy based on PDEVs may be an effective treatment for IBD, but also the intestinal barrier and intestinal microbiota will be a new direction for the treatment of IBD.http://www.sciencedirect.com/science/article/pii/S209012322400047XPlant-derived extracellular vesiclesInflammatory bowel diseaseImmune responseIntestinal barrierGut microbiota |
| spellingShingle | Jinling Li Ting Luo Dou Wang Yao Zhao Yuanxiang Jin Guiling Yang Xin Zhang Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease Journal of Advanced Research Plant-derived extracellular vesicles Inflammatory bowel disease Immune response Intestinal barrier Gut microbiota |
| title | Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease |
| title_full | Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease |
| title_fullStr | Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease |
| title_full_unstemmed | Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease |
| title_short | Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease |
| title_sort | therapeutic application and potential mechanism of plant derived extracellular vesicles in inflammatory bowel disease |
| topic | Plant-derived extracellular vesicles Inflammatory bowel disease Immune response Intestinal barrier Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S209012322400047X |
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