Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice
It is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. Recently RR was found outside the olfactory...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/4570831 |
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| author | Jakob Jessberger Weiwei Zhong Jurij Brankačk Andreas Draguhn |
| author_facet | Jakob Jessberger Weiwei Zhong Jurij Brankačk Andreas Draguhn |
| author_sort | Jakob Jessberger |
| collection | DOAJ |
| description | It is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. Recently RR was found outside the olfactory system, suggesting that it plays a role in organizing distributed network activity. It is therefore important to measure RR and to delineate it from endogenous electrical rhythms like theta which cover similar frequency bands in small rodents. In order to validate such measurements in freely behaving mice, we compared rhythmic LFP in the OB with two respiration-related biophysical parameters: whole-body plethysmography (PG) and nasal temperature (thermocouple; TC). During waking, all three signals reflected respiration with similar reliability. Peak power of RR in OB decreased with increasing respiration rate whereas power of PG increased. During NREM sleep, respiration-related TC signals disappeared and large amplitude slow waves frequently concealed RR in OB. In this situation, PG provided a reliable signal while breathing-related rhythms in TC and OB returned only during microarousals. In summary, local field potentials in the olfactory bulb do reliably reflect respiratory rhythm during wakefulness and REM sleep but not during NREM sleep. |
| format | Article |
| id | doaj-art-b3a1013d6aea48609867686fdd99965a |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b3a1013d6aea48609867686fdd99965a2025-02-03T01:27:18ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/45708314570831Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of MiceJakob Jessberger0Weiwei Zhong1Jurij Brankačk2Andreas Draguhn3Institute for Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, GermanyInstitute for Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, GermanyInstitute for Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, GermanyInstitute for Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, GermanyIt is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. Recently RR was found outside the olfactory system, suggesting that it plays a role in organizing distributed network activity. It is therefore important to measure RR and to delineate it from endogenous electrical rhythms like theta which cover similar frequency bands in small rodents. In order to validate such measurements in freely behaving mice, we compared rhythmic LFP in the OB with two respiration-related biophysical parameters: whole-body plethysmography (PG) and nasal temperature (thermocouple; TC). During waking, all three signals reflected respiration with similar reliability. Peak power of RR in OB decreased with increasing respiration rate whereas power of PG increased. During NREM sleep, respiration-related TC signals disappeared and large amplitude slow waves frequently concealed RR in OB. In this situation, PG provided a reliable signal while breathing-related rhythms in TC and OB returned only during microarousals. In summary, local field potentials in the olfactory bulb do reliably reflect respiratory rhythm during wakefulness and REM sleep but not during NREM sleep.http://dx.doi.org/10.1155/2016/4570831 |
| spellingShingle | Jakob Jessberger Weiwei Zhong Jurij Brankačk Andreas Draguhn Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice Neural Plasticity |
| title | Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice |
| title_full | Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice |
| title_fullStr | Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice |
| title_full_unstemmed | Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice |
| title_short | Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice |
| title_sort | olfactory bulb field potentials and respiration in sleep wake states of mice |
| url | http://dx.doi.org/10.1155/2016/4570831 |
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