Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application
This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which se...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/748680 |
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| author | Stephanie Da Costa Mahiran Basri Norashikin Shamsudin Hamidon Basri |
| author_facet | Stephanie Da Costa Mahiran Basri Norashikin Shamsudin Hamidon Basri |
| author_sort | Stephanie Da Costa |
| collection | DOAJ |
| description | This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which serves as a positively charged cosurfactant in the nanoemulsion system. Negatively charged nanoemulsions were formulated mainly for comparison. Freshly prepared formulations were formed with particle size less than 300 nm and showed good stability over time. The oil-in-water nanoemulsion also showed good viscosity, conductivity, and pH values. From TEM micrograph, particle size showed consistent results with the measurement using photon correlation spectroscopy. It was concluded that both positively and negatively charged nanoemulsions showed good stability and have great potential in transdermal delivery system. Though, further investigation of the drug release and drug penetration of both positively and negatively charged nanoemulsions will be studied to further prove the efficacy of nanoemulsion with hydrocortisone as a delivery system for dermal application. |
| format | Article |
| id | doaj-art-b39d97a6eb264b1cbdee7988488b13cb |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-b39d97a6eb264b1cbdee7988488b13cb2025-02-03T06:05:51ZengWileyJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/748680748680Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal ApplicationStephanie Da Costa0Mahiran Basri1Norashikin Shamsudin2Hamidon Basri3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, MalaysiaDepartment of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, MalaysiaDepartment of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, MalaysiaThis paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which serves as a positively charged cosurfactant in the nanoemulsion system. Negatively charged nanoemulsions were formulated mainly for comparison. Freshly prepared formulations were formed with particle size less than 300 nm and showed good stability over time. The oil-in-water nanoemulsion also showed good viscosity, conductivity, and pH values. From TEM micrograph, particle size showed consistent results with the measurement using photon correlation spectroscopy. It was concluded that both positively and negatively charged nanoemulsions showed good stability and have great potential in transdermal delivery system. Though, further investigation of the drug release and drug penetration of both positively and negatively charged nanoemulsions will be studied to further prove the efficacy of nanoemulsion with hydrocortisone as a delivery system for dermal application.http://dx.doi.org/10.1155/2014/748680 |
| spellingShingle | Stephanie Da Costa Mahiran Basri Norashikin Shamsudin Hamidon Basri Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application Journal of Chemistry |
| title | Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application |
| title_full | Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application |
| title_fullStr | Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application |
| title_full_unstemmed | Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application |
| title_short | Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application |
| title_sort | stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application |
| url | http://dx.doi.org/10.1155/2014/748680 |
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