Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9

Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9

Abstract Pancreatic cancer is a lethal disease with an insidious onset, and little is known about its early molecular events. Here, we found that the sterol regulatory element-binding protein 1 (SREBP1) expression is gradually upregulated during the initiation of pancreatic cancer. Through in vitro...

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Main Authors: Cancan Zhou, Zhengyuan Feng, Weikun Qian, Zeen Zhu, Ruiqi Cao, Qiqi Wang, Wunai Zhang, Rujuan Liu, Shuai Wu, Jie Hao, Zheng Wang, Qingyong Ma, Zheng Wu, Xuqi Li
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biology Direct
Subjects:
Pancreatic cancer
Tumorigenesis
Tumor growth
SREBP1
SOX9
Online Access:https://doi.org/10.1186/s13062-025-00595-1
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