<i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features
Recent advances in molecular genetics, particularly in identifying and characterizing genetic abnormalities within mesenchymal neoplasms, have led to a more comprehensive and evolving classification system. Modern technological developments in cytogenetics and next-generation sequencing have enabled...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/2/118 |
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| author | Ahmed I. Younes Haider A. Mejbel |
| author_facet | Ahmed I. Younes Haider A. Mejbel |
| author_sort | Ahmed I. Younes |
| collection | DOAJ |
| description | Recent advances in molecular genetics, particularly in identifying and characterizing genetic abnormalities within mesenchymal neoplasms, have led to a more comprehensive and evolving classification system. Modern technological developments in cytogenetics and next-generation sequencing have enabled the analysis of small clinical samples, expanded our understanding of tumor biology, and improved the diagnostic, prognostic, and predictive precision by identifying targeted genetic alterations, confirming the presence of fusion transcripts, and/or revealing the overexpression of specific genes and their targets. In this review, we focus specifically on the <i>GLI1</i>-rearranged enteric tumor, a recent clinicopathological entity that has emerged within the expanding classification of mesenchymal tumors. Herein, we aim to explore the histopathological features, molecular genetic characteristics, and clinical outcomes in these tumors. Due to their rarity and the extensive overlapping in their histopathological and molecular features with other neoplasms, continued research and systematic documentation of <i>GLI1</i>-rearranged enteric tumors is necessary to better understand their biological behavior, develop more accurate prognostic indicators, and establish optimal treatment strategies. |
| format | Article |
| id | doaj-art-b38ef4faa64541b6acc65a918ae07c0a |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-b38ef4faa64541b6acc65a918ae07c0a2025-01-24T13:26:44ZengMDPI AGCells2073-44092025-01-0114211810.3390/cells14020118<i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics FeaturesAhmed I. Younes0Haider A. Mejbel1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USARecent advances in molecular genetics, particularly in identifying and characterizing genetic abnormalities within mesenchymal neoplasms, have led to a more comprehensive and evolving classification system. Modern technological developments in cytogenetics and next-generation sequencing have enabled the analysis of small clinical samples, expanded our understanding of tumor biology, and improved the diagnostic, prognostic, and predictive precision by identifying targeted genetic alterations, confirming the presence of fusion transcripts, and/or revealing the overexpression of specific genes and their targets. In this review, we focus specifically on the <i>GLI1</i>-rearranged enteric tumor, a recent clinicopathological entity that has emerged within the expanding classification of mesenchymal tumors. Herein, we aim to explore the histopathological features, molecular genetic characteristics, and clinical outcomes in these tumors. Due to their rarity and the extensive overlapping in their histopathological and molecular features with other neoplasms, continued research and systematic documentation of <i>GLI1</i>-rearranged enteric tumors is necessary to better understand their biological behavior, develop more accurate prognostic indicators, and establish optimal treatment strategies.https://www.mdpi.com/2073-4409/14/2/118<i>GLI1</i>fusion genenext-generation sequencinggastrointestinal tumors |
| spellingShingle | Ahmed I. Younes Haider A. Mejbel <i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features Cells <i>GLI1</i> fusion gene next-generation sequencing gastrointestinal tumors |
| title | <i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features |
| title_full | <i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features |
| title_fullStr | <i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features |
| title_full_unstemmed | <i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features |
| title_short | <i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features |
| title_sort | i gli1 i rearranged enteric tumors updates on clinicopathologic and molecular genetics features |
| topic | <i>GLI1</i> fusion gene next-generation sequencing gastrointestinal tumors |
| url | https://www.mdpi.com/2073-4409/14/2/118 |
| work_keys_str_mv | AT ahmediyounes igli1irearrangedenterictumorsupdatesonclinicopathologicandmoleculargeneticsfeatures AT haideramejbel igli1irearrangedenterictumorsupdatesonclinicopathologicandmoleculargeneticsfeatures |