Association of <i>VDR</i> Polymorphisms (<i>FokI</i>, <i>ApaI</i>, and <i>TaqI</i>) with Susceptibility to Lumbar Disc Herniation: Systematic Review, Meta-Analysis, Trial Sequential Analysis, and Transcriptional Prediction

Association of <i>VDR</i> Polymorphisms (<i>FokI</i>, <i>ApaI</i>, and <i>TaqI</i>) with Susceptibility to Lumbar Disc Herniation: Systematic Review, Meta-Analysis, Trial Sequential Analysis, and Transcriptional Prediction

<i>Background and Objectives</i>: Lumbar disc herniation (LDH) is influenced by genetic, mechanical, and behavioral factors, with genetic predisposition playing a key role. <i>Vitamin D receptor</i> (<i>VDR</i>) polymorphisms have been implicated in LDH susceptibi...

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Bibliographic Details
Main Authors: Alireza Sheikhi, Mohsen Nabiuni, Soha Zia, Masoud Sadeghi, Annette B. Brühl, Serge Brand
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Medicina
Subjects:
lumbar disc herniation
vitamin D receptor
genetic polymorphism
meta-analysis
allelic variation
Online Access:https://www.mdpi.com/1648-9144/61/5/882
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