Bye-bye muscle biopsy, we have autoantibodies with us now
Muscle biopsy is generally considered the gold standard diagnostic tool for patients with presenting with features suggestive of idiopathic inflammatory myopathy. Muscle biopsy is however an invasive test, the histopathological findings can be influenced by previous treatment and not all patients wi...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=74;epage=80;aulast=Riddell |
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| _version_ | 1832568799478415360 |
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| author | Victoria Riddell Sarah L Tansley |
| author_facet | Victoria Riddell Sarah L Tansley |
| author_sort | Victoria Riddell |
| collection | DOAJ |
| description | Muscle biopsy is generally considered the gold standard diagnostic tool for patients with presenting with features suggestive of idiopathic inflammatory myopathy. Muscle biopsy is however an invasive test, the histopathological findings can be influenced by previous treatment and not all patients with myositis spectrum disease have muscle involvement. Myositis specific and associated autoantibodies can now be identified in the majority of patients with myositis. When present they identify homogeneous patient subgroups and have the potential to be key tools in developing a personalised approach to disease management. Here we review the utility of myositis specific and associated autoantibodies as diagnostic and prognostic tools. |
| format | Article |
| id | doaj-art-b3698a7c2a15429caf5604b708231644 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-b3698a7c2a15429caf5604b7082316442025-02-03T00:25:16ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-01156748010.4103/injr.injr_114_20Bye-bye muscle biopsy, we have autoantibodies with us nowVictoria RiddellSarah L TansleyMuscle biopsy is generally considered the gold standard diagnostic tool for patients with presenting with features suggestive of idiopathic inflammatory myopathy. Muscle biopsy is however an invasive test, the histopathological findings can be influenced by previous treatment and not all patients with myositis spectrum disease have muscle involvement. Myositis specific and associated autoantibodies can now be identified in the majority of patients with myositis. When present they identify homogeneous patient subgroups and have the potential to be key tools in developing a personalised approach to disease management. Here we review the utility of myositis specific and associated autoantibodies as diagnostic and prognostic tools.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=74;epage=80;aulast=Riddellautoantibodybiopsydiagnosismyopathymyositis |
| spellingShingle | Victoria Riddell Sarah L Tansley Bye-bye muscle biopsy, we have autoantibodies with us now Indian Journal of Rheumatology autoantibody biopsy diagnosis myopathy myositis |
| title | Bye-bye muscle biopsy, we have autoantibodies with us now |
| title_full | Bye-bye muscle biopsy, we have autoantibodies with us now |
| title_fullStr | Bye-bye muscle biopsy, we have autoantibodies with us now |
| title_full_unstemmed | Bye-bye muscle biopsy, we have autoantibodies with us now |
| title_short | Bye-bye muscle biopsy, we have autoantibodies with us now |
| title_sort | bye bye muscle biopsy we have autoantibodies with us now |
| topic | autoantibody biopsy diagnosis myopathy myositis |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=74;epage=80;aulast=Riddell |
| work_keys_str_mv | AT victoriariddell byebyemusclebiopsywehaveautoantibodieswithusnow AT sarahltansley byebyemusclebiopsywehaveautoantibodieswithusnow |