Malignancy in Membranous Nephropathy: Evaluation of Incidence
Background. Membranous nephropathy (MN) can be associated with malignancy. However, the relative risk for malignancy remains unclear. It has been reported that higher numbers of inflammatory cells seen in the glomeruli at biopsy correlate with the occurrence of malignancy in patients with MN and mig...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2017/8409829 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545536350093312 |
|---|---|
| author | Basil Alnasrallah John F. Collins L. Jonathan Zwi |
| author_facet | Basil Alnasrallah John F. Collins L. Jonathan Zwi |
| author_sort | Basil Alnasrallah |
| collection | DOAJ |
| description | Background. Membranous nephropathy (MN) can be associated with malignancy. However, the relative risk for malignancy remains unclear. It has been reported that higher numbers of inflammatory cells seen in the glomeruli at biopsy correlate with the occurrence of malignancy in patients with MN and might be used to direct screening. Methods. We examined the occurrence of malignancy in 201 MN patients in Auckland, New Zealand. We also examined the pathology of renal biopsies from 17 MN patients with malignancies and compared the number of inflammatory cells per glomerulus with matched control patients with MN but no malignancy. Results. 40 malignancies were identified in 37 patients, 28 of which occurred after the MN diagnosis. The standardized incidence ratio (SIR) was 2.1 (95% CI, 1.3–2.85) which was similar between patients ≥ 60 years and those <60 years. The median number of inflammatory cells per glomerulus did not differ between MN patients with and without malignancy at 1.86 (IQR, 1.17–2.7) and 2.07 (IQR, 1.17–3.65), respectively (p value 0.56). Conclusions. The relative risk of malignancy in MN patients was similar across different age groups. The number of inflammatory cells per glomerulus did not differentiate between MN patients with and without malignancies. |
| format | Article |
| id | doaj-art-b366f768c9e947cf809a21112672e996 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-b366f768c9e947cf809a21112672e9962025-02-03T07:25:40ZengWileyInternational Journal of Nephrology2090-214X2090-21582017-01-01201710.1155/2017/84098298409829Malignancy in Membranous Nephropathy: Evaluation of IncidenceBasil Alnasrallah0John F. Collins1L. Jonathan Zwi2Department of Nephrology, Auckland City Hospital, 2 Park Drive, Grafton, Auckland 1023, New ZealandDepartment of Nephrology, Auckland City Hospital, 2 Park Drive, Grafton, Auckland 1023, New ZealandDepartment of Pathology, Auckland City Hospital, 2 Park Drive, Grafton, Auckland 1023, New ZealandBackground. Membranous nephropathy (MN) can be associated with malignancy. However, the relative risk for malignancy remains unclear. It has been reported that higher numbers of inflammatory cells seen in the glomeruli at biopsy correlate with the occurrence of malignancy in patients with MN and might be used to direct screening. Methods. We examined the occurrence of malignancy in 201 MN patients in Auckland, New Zealand. We also examined the pathology of renal biopsies from 17 MN patients with malignancies and compared the number of inflammatory cells per glomerulus with matched control patients with MN but no malignancy. Results. 40 malignancies were identified in 37 patients, 28 of which occurred after the MN diagnosis. The standardized incidence ratio (SIR) was 2.1 (95% CI, 1.3–2.85) which was similar between patients ≥ 60 years and those <60 years. The median number of inflammatory cells per glomerulus did not differ between MN patients with and without malignancy at 1.86 (IQR, 1.17–2.7) and 2.07 (IQR, 1.17–3.65), respectively (p value 0.56). Conclusions. The relative risk of malignancy in MN patients was similar across different age groups. The number of inflammatory cells per glomerulus did not differentiate between MN patients with and without malignancies.http://dx.doi.org/10.1155/2017/8409829 |
| spellingShingle | Basil Alnasrallah John F. Collins L. Jonathan Zwi Malignancy in Membranous Nephropathy: Evaluation of Incidence International Journal of Nephrology |
| title | Malignancy in Membranous Nephropathy: Evaluation of Incidence |
| title_full | Malignancy in Membranous Nephropathy: Evaluation of Incidence |
| title_fullStr | Malignancy in Membranous Nephropathy: Evaluation of Incidence |
| title_full_unstemmed | Malignancy in Membranous Nephropathy: Evaluation of Incidence |
| title_short | Malignancy in Membranous Nephropathy: Evaluation of Incidence |
| title_sort | malignancy in membranous nephropathy evaluation of incidence |
| url | http://dx.doi.org/10.1155/2017/8409829 |
| work_keys_str_mv | AT basilalnasrallah malignancyinmembranousnephropathyevaluationofincidence AT johnfcollins malignancyinmembranousnephropathyevaluationofincidence AT ljonathanzwi malignancyinmembranousnephropathyevaluationofincidence |