Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES
Abstract At present, the relationship between the intake of antioxidants in food and the mortality rate of patients with chronic kidney disease (CKD), especially the association with the mortality rate of specific causes, is not clear. This study included 6379 adult CKD patients from the National He...
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Nature Portfolio
2025-01-01
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| author | Jun Sun Haoyu Yang Aru Sun Huifang Guan Weinan Xie Lin Han Yu Wei Xiaoyu Zang Pengfei Xie Xiaolin Tong Yiqun Lin |
| author_facet | Jun Sun Haoyu Yang Aru Sun Huifang Guan Weinan Xie Lin Han Yu Wei Xiaoyu Zang Pengfei Xie Xiaolin Tong Yiqun Lin |
| author_sort | Jun Sun |
| collection | DOAJ |
| description | Abstract At present, the relationship between the intake of antioxidants in food and the mortality rate of patients with chronic kidney disease (CKD), especially the association with the mortality rate of specific causes, is not clear. This study included 6379 adult CKD patients from the National Health and Nutrition Examination Survey (2001–2018). Use the Cox proportional hazards model, restricted cubic spline (RCS) model, and stratified and sensitivity analysis to evaluate the relationship between the Composite Dietary Antioxidant Index (CDAI) and mortality in patients with chronic kidney disease. During the follow-up period, 2381 all-cause deaths were recorded, including 719 deaths from cardiovascular disease, 132 deaths from cerebrovascular disease, and 430 deaths from cancer. We found that compared to the lowest quartile of CDAI, the weighted multivariate hazard ratio of participants in the highest quartile was 0.83 (95% confidence interval: 0.72, 0.96) for all-cause mortality, Cardiovascular mortality was 0.91 (95% confidence interval: 0.70, 1.18), Cerebrovascular death was 0.51 (95% confidence interval: 0.24, 1.07), Death due to cancer was 0.64 (95% confidence interval: 0.45, 0.92). RCS analysis shows a non-linear relationship between CDAI and all-cause mortality and cancer mortality. At the same time, there is no non-linear relationship between CDAI and cardiovascular mortality and cerebrovascular mortality. Stratified analysis shows that race and BMI are influencing factors for CDAI-CKD mortality. Sensitivity analysis confirmed the robustness of the results. Our research findings emphasize the potential advantages of an antioxidant diet in reducing the risk of mortality in CKD patients. |
| format | Article |
| id | doaj-art-b360d402717b4cc4bbced709a0ed3e24 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b360d402717b4cc4bbced709a0ed3e242025-01-26T12:25:37ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-87230-1Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANESJun Sun0Haoyu Yang1Aru Sun2Huifang Guan3Weinan Xie4Lin Han5Yu Wei6Xiaoyu Zang7Pengfei Xie8Xiaolin Tong9Yiqun Lin10Changchun University of Traditional Chinese MedicineGuang’anmen Hospital, China Academy of Chinese Medical SciencesChangchun University of Traditional Chinese MedicineChangchun University of Traditional Chinese MedicineGuang’anmen Hospital, China Academy of Chinese Medical SciencesInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing University of Traditional Chinese MedicineChangchun University of Traditional Chinese MedicineBeijing University of Traditional Chinese MedicineInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical SciencesGuang’anmen Hospital South Campus, China Academy of Chinese Medical SciencesAbstract At present, the relationship between the intake of antioxidants in food and the mortality rate of patients with chronic kidney disease (CKD), especially the association with the mortality rate of specific causes, is not clear. This study included 6379 adult CKD patients from the National Health and Nutrition Examination Survey (2001–2018). Use the Cox proportional hazards model, restricted cubic spline (RCS) model, and stratified and sensitivity analysis to evaluate the relationship between the Composite Dietary Antioxidant Index (CDAI) and mortality in patients with chronic kidney disease. During the follow-up period, 2381 all-cause deaths were recorded, including 719 deaths from cardiovascular disease, 132 deaths from cerebrovascular disease, and 430 deaths from cancer. We found that compared to the lowest quartile of CDAI, the weighted multivariate hazard ratio of participants in the highest quartile was 0.83 (95% confidence interval: 0.72, 0.96) for all-cause mortality, Cardiovascular mortality was 0.91 (95% confidence interval: 0.70, 1.18), Cerebrovascular death was 0.51 (95% confidence interval: 0.24, 1.07), Death due to cancer was 0.64 (95% confidence interval: 0.45, 0.92). RCS analysis shows a non-linear relationship between CDAI and all-cause mortality and cancer mortality. At the same time, there is no non-linear relationship between CDAI and cardiovascular mortality and cerebrovascular mortality. Stratified analysis shows that race and BMI are influencing factors for CDAI-CKD mortality. Sensitivity analysis confirmed the robustness of the results. Our research findings emphasize the potential advantages of an antioxidant diet in reducing the risk of mortality in CKD patients.https://doi.org/10.1038/s41598-025-87230-1CDAINHANESCKDMortalityAll-causeCause-specific |
| spellingShingle | Jun Sun Haoyu Yang Aru Sun Huifang Guan Weinan Xie Lin Han Yu Wei Xiaoyu Zang Pengfei Xie Xiaolin Tong Yiqun Lin Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES Scientific Reports CDAI NHANES CKD Mortality All-cause Cause-specific |
| title | Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES |
| title_full | Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES |
| title_fullStr | Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES |
| title_full_unstemmed | Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES |
| title_short | Association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in NHANES |
| title_sort | association of composite dietary antioxidant index with mortality risk among adults with chronic kidney disease in nhanes |
| topic | CDAI NHANES CKD Mortality All-cause Cause-specific |
| url | https://doi.org/10.1038/s41598-025-87230-1 |
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