Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications
Background: Diabetes mellitus is a metabolic disease that can lead to macrovascular and microvascular complications that can cause death and reduce the quality of life. The level of serum AGEs increases with diabetes or a state of hyperglycemia. Increased AGEs in patients with diabetes mellitus can...
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Bucharest College of Physicians
2023-06-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2023/06/Differences-in-AGEs-and-hs-CRP-between-Type-2-Diabetes-Mellitus-with-and-without-Complications.pdf |
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| author | Alfino Validita SIDIQ Yetti HERNANINGSIH Puspa WARDHANI Soebagijo Adi SOELISTIJO |
| author_facet | Alfino Validita SIDIQ Yetti HERNANINGSIH Puspa WARDHANI Soebagijo Adi SOELISTIJO |
| author_sort | Alfino Validita SIDIQ |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a metabolic disease that can lead to macrovascular and microvascular complications that can cause death and reduce the quality of life. The level of serum AGEs increases with diabetes or a state of hyperglycemia. Increased AGEs in patients with diabetes mellitus can increase the risk of macrovascular and microvascular complications and increase the formation of hs-CRP. This study aims to assess the differences in AGEs and hs-CRP between type 2 diabetes mellitus patients with and without complications and the relationship between AGEs and hs-CRP. Methods: A cross-sectional study was conducted with 30 subjects of type 2 diabetes mellitus with complications and 30 subjects of diabetes mellitus without complications. Data were collected from September to December 2022. AGEs were measured using ELISA and hs-CRP using the turbidimetric method. Data were statistically processed to determine the difference and relationship between AGEs and hs-CRP. Results: AGEs and hs-CRP values in patients with type 2 diabetes mellitus with complications were 0.671±0.194 ng/ mL and 2.08(0.98-15.3) mg/L. In patients with uncomplicated type 2 diabetes 0.561±0.127 ng/mL and 1.69(0.22-9.25) mg/L. Differences in AGEs and hs-CRP between the two subject groups had significant results (AGEs p=0.012, hs-CRP p=0.038). The relationship between AGEs and hs-CRP in each subject group showed no significant results (With complications r=0.659 p=0.659, Without complications r=0.253 p=0.253). Conclusion: There are differences in AGEs and hs-CRP values between patients with type 2 diabetes mellitus with and without complications and there is no relationship between AGEs and hs-CRP values in each subject. |
| format | Article |
| id | doaj-art-b35a6d0b0b8149b190332ef10271bbd0 |
| institution | OA Journals |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-b35a6d0b0b8149b190332ef10271bbd02025-08-20T02:23:24ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732023-06-01302117124https://doi.org/10.31689/rmm.2023.30.2.117Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without ComplicationsAlfino Validita SIDIQ0Yetti HERNANINGSIH1https://orcid.org/0000-0001-8773-8267Puspa WARDHANI2https://orcid.org/0000-0003-2202-8090Soebagijo Adi SOELISTIJO3Postgraduate Student, Basic Medical Science Master Program, Faculty of Medicine Universitas Airlangga, Surabaya, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine Airlangga University, Surabaya, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaBackground: Diabetes mellitus is a metabolic disease that can lead to macrovascular and microvascular complications that can cause death and reduce the quality of life. The level of serum AGEs increases with diabetes or a state of hyperglycemia. Increased AGEs in patients with diabetes mellitus can increase the risk of macrovascular and microvascular complications and increase the formation of hs-CRP. This study aims to assess the differences in AGEs and hs-CRP between type 2 diabetes mellitus patients with and without complications and the relationship between AGEs and hs-CRP. Methods: A cross-sectional study was conducted with 30 subjects of type 2 diabetes mellitus with complications and 30 subjects of diabetes mellitus without complications. Data were collected from September to December 2022. AGEs were measured using ELISA and hs-CRP using the turbidimetric method. Data were statistically processed to determine the difference and relationship between AGEs and hs-CRP. Results: AGEs and hs-CRP values in patients with type 2 diabetes mellitus with complications were 0.671±0.194 ng/ mL and 2.08(0.98-15.3) mg/L. In patients with uncomplicated type 2 diabetes 0.561±0.127 ng/mL and 1.69(0.22-9.25) mg/L. Differences in AGEs and hs-CRP between the two subject groups had significant results (AGEs p=0.012, hs-CRP p=0.038). The relationship between AGEs and hs-CRP in each subject group showed no significant results (With complications r=0.659 p=0.659, Without complications r=0.253 p=0.253). Conclusion: There are differences in AGEs and hs-CRP values between patients with type 2 diabetes mellitus with and without complications and there is no relationship between AGEs and hs-CRP values in each subject.https://medicinamoderna.ro/wp-content/uploads/2023/06/Differences-in-AGEs-and-hs-CRP-between-Type-2-Diabetes-Mellitus-with-and-without-Complications.pdfdiabetes mellitus type 2ageshs-crpcomplication |
| spellingShingle | Alfino Validita SIDIQ Yetti HERNANINGSIH Puspa WARDHANI Soebagijo Adi SOELISTIJO Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications Modern Medicine diabetes mellitus type 2 ages hs-crp complication |
| title | Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications |
| title_full | Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications |
| title_fullStr | Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications |
| title_full_unstemmed | Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications |
| title_short | Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications |
| title_sort | differences in ages and hs crp between type 2 diabetes mellitus with and without complications |
| topic | diabetes mellitus type 2 ages hs-crp complication |
| url | https://medicinamoderna.ro/wp-content/uploads/2023/06/Differences-in-AGEs-and-hs-CRP-between-Type-2-Diabetes-Mellitus-with-and-without-Complications.pdf |
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