Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancer
Abstract Background Lymphatic leakage is a common complication after radical cystectomy and pelvic lymph node dissection (PLND) for muscle-invasive bladder cancer (MIBC).This study aimed to investigate the risk factors contributing to postoperative lymphatic leakage in patients with MIBC. Materials...
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| Format: | Article |
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BMC
2025-01-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03683-8 |
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| author | Zixuan Xue Ye Yan Huiying Chen Hai Mao Tianwu Ma Guoliang Wang Hongxian Zhang Lulin Ma Jianfei Ye Kai Hong Fan Zhang Shudong Zhang |
| author_facet | Zixuan Xue Ye Yan Huiying Chen Hai Mao Tianwu Ma Guoliang Wang Hongxian Zhang Lulin Ma Jianfei Ye Kai Hong Fan Zhang Shudong Zhang |
| author_sort | Zixuan Xue |
| collection | DOAJ |
| description | Abstract Background Lymphatic leakage is a common complication after radical cystectomy and pelvic lymph node dissection (PLND) for muscle-invasive bladder cancer (MIBC).This study aimed to investigate the risk factors contributing to postoperative lymphatic leakage in patients with MIBC. Materials and methods A total of 534 patients undergoing radical cystectomy and PLND were enrolled in the retrospective study at Peking University Third Hospital from January 2010 to July 2023. Patients were categorized into lymphatic leakage(n = 254)and non-leakage groups (n = 280) and compared demographic, perioperativ and pathologic factors. Multivariate logistic regression was applied to identify risk factors for lymphatic leakage. Spearman correlation was used to analyze the relationship between lymph leakage ratio and risk factors. Results Patients with lymphatic leakage had significantly higher rates of receiving extended PLND (19.7% vs. 11.4%, p = 0.008), higher total number of dissected lymph nodes (median 11 vs. 8, p < 0.001), longer hospital stays (median 13 vs. 11 days, p < 0.001), higher postoperative hypoalbuminemia rate (56.7% vs. 36.4%, p < 0.001) and higher fever rate (14.2% vs. 8.6%, p = 0.04) compared to the non-leakage group. On multivariate analysis, higher number of dissected lymph nodes (OR 3.278, 95% CI 1.135–9.471, p = 0.028) was found to be a independent risk factor for lymphatic leakage. Additionally, a positive correlation was observed between the numbers of dissected lymph nodes and lymphatic leakage rate (R = 0.456, p = 0.013). Conclusions The increased number of dissected lymph nodes is associated with a heightened risk of lymphatic leakage following radical cystectomy for MIBC. |
| format | Article |
| id | doaj-art-b347c67194ec4ceca4cc84b58d83f2cc |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-b347c67194ec4ceca4cc84b58d83f2cc2025-01-26T12:36:31ZengBMCWorld Journal of Surgical Oncology1477-78192025-01-0123111210.1186/s12957-025-03683-8Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancerZixuan Xue0Ye Yan1Huiying Chen2Hai Mao3Tianwu Ma4Guoliang Wang5Hongxian Zhang6Lulin Ma7Jianfei Ye8Kai Hong9Fan Zhang10Shudong Zhang11Department of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalDepartment of Radiology, Peking University Third HospitalDepartment of Urology, Fengjie County Hospital of Chinese MedicineDepartment of Urology, Qianwei HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalAbstract Background Lymphatic leakage is a common complication after radical cystectomy and pelvic lymph node dissection (PLND) for muscle-invasive bladder cancer (MIBC).This study aimed to investigate the risk factors contributing to postoperative lymphatic leakage in patients with MIBC. Materials and methods A total of 534 patients undergoing radical cystectomy and PLND were enrolled in the retrospective study at Peking University Third Hospital from January 2010 to July 2023. Patients were categorized into lymphatic leakage(n = 254)and non-leakage groups (n = 280) and compared demographic, perioperativ and pathologic factors. Multivariate logistic regression was applied to identify risk factors for lymphatic leakage. Spearman correlation was used to analyze the relationship between lymph leakage ratio and risk factors. Results Patients with lymphatic leakage had significantly higher rates of receiving extended PLND (19.7% vs. 11.4%, p = 0.008), higher total number of dissected lymph nodes (median 11 vs. 8, p < 0.001), longer hospital stays (median 13 vs. 11 days, p < 0.001), higher postoperative hypoalbuminemia rate (56.7% vs. 36.4%, p < 0.001) and higher fever rate (14.2% vs. 8.6%, p = 0.04) compared to the non-leakage group. On multivariate analysis, higher number of dissected lymph nodes (OR 3.278, 95% CI 1.135–9.471, p = 0.028) was found to be a independent risk factor for lymphatic leakage. Additionally, a positive correlation was observed between the numbers of dissected lymph nodes and lymphatic leakage rate (R = 0.456, p = 0.013). Conclusions The increased number of dissected lymph nodes is associated with a heightened risk of lymphatic leakage following radical cystectomy for MIBC.https://doi.org/10.1186/s12957-025-03683-8Lymphatic leakageMuscle-invasive bladder cancerRadical cystectomyPelvic lymph node dissection |
| spellingShingle | Zixuan Xue Ye Yan Huiying Chen Hai Mao Tianwu Ma Guoliang Wang Hongxian Zhang Lulin Ma Jianfei Ye Kai Hong Fan Zhang Shudong Zhang Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancer World Journal of Surgical Oncology Lymphatic leakage Muscle-invasive bladder cancer Radical cystectomy Pelvic lymph node dissection |
| title | Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancer |
| title_full | Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancer |
| title_fullStr | Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancer |
| title_full_unstemmed | Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancer |
| title_short | Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancer |
| title_sort | risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle invasive bladder cancer |
| topic | Lymphatic leakage Muscle-invasive bladder cancer Radical cystectomy Pelvic lymph node dissection |
| url | https://doi.org/10.1186/s12957-025-03683-8 |
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