Arterial Hemodynamics in Prehypertensives
Compared to age-matched normotensive adults, those with essential hypertension have been shown to have distinct arterial hemodynamic abnormalities consisting of increased peripheral resistance, pulse wave velocity, and wave reflection magnitude as well as decreased wave reflection time and aortic co...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2019/3961723 |
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| author | Chih-Tai Ting Jaw-Wen Chen Mau-Song Chang Frank Chi-Pong Yin |
| author_facet | Chih-Tai Ting Jaw-Wen Chen Mau-Song Chang Frank Chi-Pong Yin |
| author_sort | Chih-Tai Ting |
| collection | DOAJ |
| description | Compared to age-matched normotensive adults, those with essential hypertension have been shown to have distinct arterial hemodynamic abnormalities consisting of increased peripheral resistance, pulse wave velocity, and wave reflection magnitude as well as decreased wave reflection time and aortic compliance. These abnormalities are further exacerbated by beta-adrenergic blockade. To see if there are similar hemodynamic abnormalities that antedate the onset of fixed hypertension, we compared age-matched normotensives with prehypertensives selected from patients undergoing diagnostic cardiac catheterization. Ascending aortic pressure and flow were measured with a micromanometer and flow velocity sensor in the baseline state and after beta-adrenergic blockade. In the baseline state the prehypertensive compared to the normotensive group had elevated blood pressure, resistance, left ventricular end-diastolic pressure (LVEDP), and wave reflections. Beta-adrenergic blockade increased resistance, LVEDP, and wave reflections in both groups. Some of these findings are the same as those we previously reported in young persons with established, essential hypertension. The differences in LVEDP and wave reflections, both in the baseline state and after beta-blockade, were still present in subgroups with no differences in blood pressure. Hence, the elevated wave reflections in prehypertensives do not appear to be directly related to the level of blood pressure. These results support the notion that the elevated blood pressure in hypertension may represent a later manifestation of an already abnormal vascular system rather than the vascular abnormalities resulting from hypertension. Consequently, even before blood pressure becomes elevated, early diagnosis and treatment of the vascular abnormalities in prehypertensives may be warranted. |
| format | Article |
| id | doaj-art-b33fb2bb2e11428eb2c4d3454d453bc0 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-b33fb2bb2e11428eb2c4d3454d453bc02025-02-03T05:50:59ZengWileyInternational Journal of Hypertension2090-03842090-03922019-01-01201910.1155/2019/39617233961723Arterial Hemodynamics in PrehypertensivesChih-Tai Ting0Jaw-Wen Chen1Mau-Song Chang2Frank Chi-Pong Yin3Cardiovascular Center, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Medical Research, Veterans General Hospital, Taipei, TaiwanCardiology Division, Department of Medicine, Veterans General Hospital, Taipei, TaiwanDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USACompared to age-matched normotensive adults, those with essential hypertension have been shown to have distinct arterial hemodynamic abnormalities consisting of increased peripheral resistance, pulse wave velocity, and wave reflection magnitude as well as decreased wave reflection time and aortic compliance. These abnormalities are further exacerbated by beta-adrenergic blockade. To see if there are similar hemodynamic abnormalities that antedate the onset of fixed hypertension, we compared age-matched normotensives with prehypertensives selected from patients undergoing diagnostic cardiac catheterization. Ascending aortic pressure and flow were measured with a micromanometer and flow velocity sensor in the baseline state and after beta-adrenergic blockade. In the baseline state the prehypertensive compared to the normotensive group had elevated blood pressure, resistance, left ventricular end-diastolic pressure (LVEDP), and wave reflections. Beta-adrenergic blockade increased resistance, LVEDP, and wave reflections in both groups. Some of these findings are the same as those we previously reported in young persons with established, essential hypertension. The differences in LVEDP and wave reflections, both in the baseline state and after beta-blockade, were still present in subgroups with no differences in blood pressure. Hence, the elevated wave reflections in prehypertensives do not appear to be directly related to the level of blood pressure. These results support the notion that the elevated blood pressure in hypertension may represent a later manifestation of an already abnormal vascular system rather than the vascular abnormalities resulting from hypertension. Consequently, even before blood pressure becomes elevated, early diagnosis and treatment of the vascular abnormalities in prehypertensives may be warranted.http://dx.doi.org/10.1155/2019/3961723 |
| spellingShingle | Chih-Tai Ting Jaw-Wen Chen Mau-Song Chang Frank Chi-Pong Yin Arterial Hemodynamics in Prehypertensives International Journal of Hypertension |
| title | Arterial Hemodynamics in Prehypertensives |
| title_full | Arterial Hemodynamics in Prehypertensives |
| title_fullStr | Arterial Hemodynamics in Prehypertensives |
| title_full_unstemmed | Arterial Hemodynamics in Prehypertensives |
| title_short | Arterial Hemodynamics in Prehypertensives |
| title_sort | arterial hemodynamics in prehypertensives |
| url | http://dx.doi.org/10.1155/2019/3961723 |
| work_keys_str_mv | AT chihtaiting arterialhemodynamicsinprehypertensives AT jawwenchen arterialhemodynamicsinprehypertensives AT mausongchang arterialhemodynamicsinprehypertensives AT frankchipongyin arterialhemodynamicsinprehypertensives |