The role of ubiquitination and deubiquitination in cancer lipid metabolism
The ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome. Lipid metabolism plays a crucial role in cellular energy metabolism and is c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1464914/full |
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| author | Yongkang Xu Jiayu Zeng Shumin Fu Kan Liu Ye Mao Si Tao Jianbing Wu |
| author_facet | Yongkang Xu Jiayu Zeng Shumin Fu Kan Liu Ye Mao Si Tao Jianbing Wu |
| author_sort | Yongkang Xu |
| collection | DOAJ |
| description | The ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome. Lipid metabolism plays a crucial role in cellular energy metabolism and is closely associated with the occurrence and development of cancers. Recent research indicates that cancer lipid metabolism is regulated by intracellular proteins, including ubiquitination modifications. This review will explore the role of ubiquitination in regulating cancer lipid metabolism, summarize the latest research progress, and propose potential therapeutic strategies. |
| format | Article |
| id | doaj-art-b33b2e2ed1404d0491a48798067b0d1d |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-b33b2e2ed1404d0491a48798067b0d1d2025-01-29T05:21:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.14649141464914The role of ubiquitination and deubiquitination in cancer lipid metabolismYongkang Xu0Jiayu Zeng1Shumin Fu2Kan Liu3Ye Mao4Si Tao5Jianbing Wu6Department of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Pediatric Surgery, Jiangxi Provincial Children’s Medical Center, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, ChinaDepartment of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaThe ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome. Lipid metabolism plays a crucial role in cellular energy metabolism and is closely associated with the occurrence and development of cancers. Recent research indicates that cancer lipid metabolism is regulated by intracellular proteins, including ubiquitination modifications. This review will explore the role of ubiquitination in regulating cancer lipid metabolism, summarize the latest research progress, and propose potential therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fonc.2025.1464914/fullubiquitinationdeubiquitinationcancerlipidmetabolism |
| spellingShingle | Yongkang Xu Jiayu Zeng Shumin Fu Kan Liu Ye Mao Si Tao Jianbing Wu The role of ubiquitination and deubiquitination in cancer lipid metabolism Frontiers in Oncology ubiquitination deubiquitination cancer lipid metabolism |
| title | The role of ubiquitination and deubiquitination in cancer lipid metabolism |
| title_full | The role of ubiquitination and deubiquitination in cancer lipid metabolism |
| title_fullStr | The role of ubiquitination and deubiquitination in cancer lipid metabolism |
| title_full_unstemmed | The role of ubiquitination and deubiquitination in cancer lipid metabolism |
| title_short | The role of ubiquitination and deubiquitination in cancer lipid metabolism |
| title_sort | role of ubiquitination and deubiquitination in cancer lipid metabolism |
| topic | ubiquitination deubiquitination cancer lipid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1464914/full |
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