Does maternal consumption of nutritive and non-nutritive sweeteners result in offspring hypertension?
The consumption of nutritive and non-nutritive sweeteners (NNS) has increased significantly in recent decades. The nutritional status of pregnant women plays a crucial role in determining the likelihood of their offspring developing hypertension in adulthood. While NNSs provide a sweet taste without...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1464269/full |
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| author | You-Lin Tain You-Lin Tain You-Lin Tain Chien-Ning Hsu Chien-Ning Hsu |
| author_facet | You-Lin Tain You-Lin Tain You-Lin Tain Chien-Ning Hsu Chien-Ning Hsu |
| author_sort | You-Lin Tain |
| collection | DOAJ |
| description | The consumption of nutritive and non-nutritive sweeteners (NNS) has increased significantly in recent decades. The nutritional status of pregnant women plays a crucial role in determining the likelihood of their offspring developing hypertension in adulthood. While NNSs provide a sweet taste without adding to sugar intake, emerging evidence suggests that maternal consumption of not only nutritive sweeteners (such as fructose) but also NNS may lead to adverse outcomes in offspring, including hypertension. This review provides an overview of the latest research connecting maternal intake of sweeteners to the long-term risk of hypertension in offspring. We examine proposed mechanisms underlying the programming of offspring hypertension by sweeteners, encompassing oxidative stress, dysregulated nutrient sensing signals, abnormal renin-angiotensin system, transcriptome changes, and dysbiotic gut microbiota. Additionally, we outline preventive strategies that can help alleviate offspring hypertension programmed by maternal diets high in sweeteners. Recent advancements in understanding the mechanisms through which maternal consumption of nutritive and non-nutritive sweeteners contributes to offspring hypertension offer promise for addressing this widespread health concern at its developmental roots. Nonetheless, further research is needed to educate the public about the safety of sweetener consumption during pregnancy and lactation. |
| format | Article |
| id | doaj-art-b3271a0c5226450890de6bc6e7bf75e0 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-b3271a0c5226450890de6bc6e7bf75e02025-01-22T05:19:42ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.14642691464269Does maternal consumption of nutritive and non-nutritive sweeteners result in offspring hypertension?You-Lin Tain0You-Lin Tain1You-Lin Tain2Chien-Ning Hsu3Chien-Ning Hsu4Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanSchool of Pharmacy, Kaohsiung Medical University, Kaohsiung, TaiwanThe consumption of nutritive and non-nutritive sweeteners (NNS) has increased significantly in recent decades. The nutritional status of pregnant women plays a crucial role in determining the likelihood of their offspring developing hypertension in adulthood. While NNSs provide a sweet taste without adding to sugar intake, emerging evidence suggests that maternal consumption of not only nutritive sweeteners (such as fructose) but also NNS may lead to adverse outcomes in offspring, including hypertension. This review provides an overview of the latest research connecting maternal intake of sweeteners to the long-term risk of hypertension in offspring. We examine proposed mechanisms underlying the programming of offspring hypertension by sweeteners, encompassing oxidative stress, dysregulated nutrient sensing signals, abnormal renin-angiotensin system, transcriptome changes, and dysbiotic gut microbiota. Additionally, we outline preventive strategies that can help alleviate offspring hypertension programmed by maternal diets high in sweeteners. Recent advancements in understanding the mechanisms through which maternal consumption of nutritive and non-nutritive sweeteners contributes to offspring hypertension offer promise for addressing this widespread health concern at its developmental roots. Nonetheless, further research is needed to educate the public about the safety of sweetener consumption during pregnancy and lactation.https://www.frontiersin.org/articles/10.3389/fnut.2025.1464269/fulldevelopmental origins of health and diseasepregnancysweetenerhypertensionfructosesugar |
| spellingShingle | You-Lin Tain You-Lin Tain You-Lin Tain Chien-Ning Hsu Chien-Ning Hsu Does maternal consumption of nutritive and non-nutritive sweeteners result in offspring hypertension? Frontiers in Nutrition developmental origins of health and disease pregnancy sweetener hypertension fructose sugar |
| title | Does maternal consumption of nutritive and non-nutritive sweeteners result in offspring hypertension? |
| title_full | Does maternal consumption of nutritive and non-nutritive sweeteners result in offspring hypertension? |
| title_fullStr | Does maternal consumption of nutritive and non-nutritive sweeteners result in offspring hypertension? |
| title_full_unstemmed | Does maternal consumption of nutritive and non-nutritive sweeteners result in offspring hypertension? |
| title_short | Does maternal consumption of nutritive and non-nutritive sweeteners result in offspring hypertension? |
| title_sort | does maternal consumption of nutritive and non nutritive sweeteners result in offspring hypertension |
| topic | developmental origins of health and disease pregnancy sweetener hypertension fructose sugar |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1464269/full |
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