Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye?
Fibroblastic reticular cells (FRCs) are stromal cells found in secondary lymphoid organ. Despite its structural function in the lymph nodes being well established, recent studies indicate that the FRCs also play a key role in immunological processes, associated with cell transit, immune response, an...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/402038 |
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| author | H. G. Alvarenga L. Marti |
| author_facet | H. G. Alvarenga L. Marti |
| author_sort | H. G. Alvarenga |
| collection | DOAJ |
| description | Fibroblastic reticular cells (FRCs) are stromal cells found in secondary lymphoid organ. Despite its structural function in the lymph nodes being well established, recent studies indicate that the FRCs also play a key role in immunological processes, associated with cell transit, immune response, and cells activation quality, and contribute to peripheral tolerance. To this end, we focus this review on lymph nodes FRC characterization and discuss functional aspects such as production of cytokines and chemokines and their involvement in the immune response, seeking to establish whether certain subsets have a more functional specialization. |
| format | Article |
| id | doaj-art-b32320cd7af54e15b225c15509743df1 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b32320cd7af54e15b225c15509743df12025-02-03T05:58:34ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/402038402038Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye?H. G. Alvarenga0L. Marti1Experimental Research, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, 05152 000 São Paulo, SP, BrazilExperimental Research, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, 05152 000 São Paulo, SP, BrazilFibroblastic reticular cells (FRCs) are stromal cells found in secondary lymphoid organ. Despite its structural function in the lymph nodes being well established, recent studies indicate that the FRCs also play a key role in immunological processes, associated with cell transit, immune response, and cells activation quality, and contribute to peripheral tolerance. To this end, we focus this review on lymph nodes FRC characterization and discuss functional aspects such as production of cytokines and chemokines and their involvement in the immune response, seeking to establish whether certain subsets have a more functional specialization.http://dx.doi.org/10.1155/2014/402038 |
| spellingShingle | H. G. Alvarenga L. Marti Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye? Journal of Immunology Research |
| title | Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye? |
| title_full | Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye? |
| title_fullStr | Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye? |
| title_full_unstemmed | Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye? |
| title_short | Multifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye? |
| title_sort | multifunctional roles of reticular fibroblastic cells more than meets the eye |
| url | http://dx.doi.org/10.1155/2014/402038 |
| work_keys_str_mv | AT hgalvarenga multifunctionalrolesofreticularfibroblasticcellsmorethanmeetstheeye AT lmarti multifunctionalrolesofreticularfibroblasticcellsmorethanmeetstheeye |