A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus

A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus

The aberrant activity of CD4+ T cells in patients with systemic lupus erythematosus (SLE) is associated with DNA hypomethylation of the regulatory regions in CD11a and CD70 genes. Our previous studies demonstrated that Gadd45a contributes to the development of SLE by promoting DNA demethylation in C...

Full description

Saved in:
Bibliographic Details
Main Authors: Yaping Li, Chenghui Huang, Ming Zhao, Gongping Liang, Rong Xiao, Susan Yung, Tak Mao Chan, Qianjin Lu
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/206298
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items