Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes
Purpose. To evaluate the predictive factors of long-term visual outcomes in neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF) agents. Methods. Unicentric retrospective review of patients with nAMD treated with anti-VEGF agents. Visual...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/4263017 |
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| author | Ana Catarina Pedrosa Tiago Sousa João Pinheiro-Costa João Beato Manuel S. Falcão Fernando Falcão-Reis Angela Carneiro |
| author_facet | Ana Catarina Pedrosa Tiago Sousa João Pinheiro-Costa João Beato Manuel S. Falcão Fernando Falcão-Reis Angela Carneiro |
| author_sort | Ana Catarina Pedrosa |
| collection | DOAJ |
| description | Purpose. To evaluate the predictive factors of long-term visual outcomes in neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF) agents. Methods. Unicentric retrospective review of patients with nAMD treated with anti-VEGF agents. Visual outcomes, 12 and 60 months after diagnosis, were evaluated. In an attempt to identify predictive factors of visual outcomes, multiple variables (demographic and epidemiological characteristics, angiographic and tomographic features) were analyzed, at baseline and during follow-up. Results. One hundred and seventeen patients were included. In multivariate analysis, baseline best-corrected visual acuity was associated with all visual endpoints at 12 and 60 months. Additionally, age, gender, number of injections, and development of subretinal fibrosis during follow-up were also significant predictors of visual outcomes at 60 months. Conclusions. Several factors can be useful in clinical practice as predictors of visual outcomes in response to anti-VEGF treatment of nAMD. |
| format | Article |
| id | doaj-art-b313f73857564e42a15dda35c0d9c70c |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-b313f73857564e42a15dda35c0d9c70c2025-02-03T01:26:02ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/42630174263017Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual OutcomesAna Catarina Pedrosa0Tiago Sousa1João Pinheiro-Costa2João Beato3Manuel S. Falcão4Fernando Falcão-Reis5Angela Carneiro6Department of Ophthalmology, Centro Hospitalar São João, Porto, PortugalDepartment of Sense Organs, Faculty of Medicine of the University of Porto, Porto, PortugalDepartment of Ophthalmology, Centro Hospitalar São João, Porto, PortugalDepartment of Ophthalmology, Centro Hospitalar São João, Porto, PortugalDepartment of Ophthalmology, Centro Hospitalar São João, Porto, PortugalDepartment of Ophthalmology, Centro Hospitalar São João, Porto, PortugalDepartment of Ophthalmology, Centro Hospitalar São João, Porto, PortugalPurpose. To evaluate the predictive factors of long-term visual outcomes in neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF) agents. Methods. Unicentric retrospective review of patients with nAMD treated with anti-VEGF agents. Visual outcomes, 12 and 60 months after diagnosis, were evaluated. In an attempt to identify predictive factors of visual outcomes, multiple variables (demographic and epidemiological characteristics, angiographic and tomographic features) were analyzed, at baseline and during follow-up. Results. One hundred and seventeen patients were included. In multivariate analysis, baseline best-corrected visual acuity was associated with all visual endpoints at 12 and 60 months. Additionally, age, gender, number of injections, and development of subretinal fibrosis during follow-up were also significant predictors of visual outcomes at 60 months. Conclusions. Several factors can be useful in clinical practice as predictors of visual outcomes in response to anti-VEGF treatment of nAMD.http://dx.doi.org/10.1155/2017/4263017 |
| spellingShingle | Ana Catarina Pedrosa Tiago Sousa João Pinheiro-Costa João Beato Manuel S. Falcão Fernando Falcão-Reis Angela Carneiro Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes Journal of Ophthalmology |
| title | Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes |
| title_full | Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes |
| title_fullStr | Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes |
| title_full_unstemmed | Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes |
| title_short | Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes |
| title_sort | treatment of neovascular age related macular degeneration with anti vegf agents predictive factors of long term visual outcomes |
| url | http://dx.doi.org/10.1155/2017/4263017 |
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