Dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates inflammation and autophagy in mice hindlimb ischemia–reperfusion injury

Dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates inflammation and autophagy in mice hindlimb ischemia–reperfusion injury

Abstract Background Ischemia-reperfusion injury (I/R) for skeletal muscle usually results from vascular injuries or trauma. Sitagliptin (STG) is an effective member of the dipeptidyl peptidase-4 (DPP-4) inhibitors drug family that plays roles in oxidative stress regulation, inflammation, and autopha...

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Bibliographic Details
Main Authors: Marwa Abdeltawab Mohammed, Dalia Abdel-Wahab Mohamed, Asmaa A. Abo Zeid, Marian F. L. Abdelmalak, Maha Tarek Mohamed, Dina Sayed Abdelrahim
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:Beni-Suef University Journal of Basic and Applied Sciences
Subjects:
Ischemia–reperfusion injury
LnRNAH19
Autophagy
Sitagliptin
ATG7
Online Access:https://doi.org/10.1186/s43088-024-00558-x
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