Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study
Abstract Background The evidence on the relationship of dietary antioxidant nutrients with the survival of ovarian cancer (OC) remains scarce. Objective This study aimed to investigate these associations in a prospective cohort of Chinese patients with OC. Methods In this prospective cohort study, p...
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-06041-6 |
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| author | Dong-Dong Wang Ming-Qian Jia He-Li Xu Yu Li Jia-Xin Liu Jia-Cheng Liu Jia-Nan Sun Fan Cao Lang Wu Fang-Hua Liu Yi-Zi Li Yi-Fan Wei Xiao-Ying Li Qian Xiao Song Gao Dong-Hui Huang Tao Zhang Ting-Ting Gong Qi-Jun Wu |
| author_facet | Dong-Dong Wang Ming-Qian Jia He-Li Xu Yu Li Jia-Xin Liu Jia-Cheng Liu Jia-Nan Sun Fan Cao Lang Wu Fang-Hua Liu Yi-Zi Li Yi-Fan Wei Xiao-Ying Li Qian Xiao Song Gao Dong-Hui Huang Tao Zhang Ting-Ting Gong Qi-Jun Wu |
| author_sort | Dong-Dong Wang |
| collection | DOAJ |
| description | Abstract Background The evidence on the relationship of dietary antioxidant nutrients with the survival of ovarian cancer (OC) remains scarce. Objective This study aimed to investigate these associations in a prospective cohort of Chinese patients with OC. Methods In this prospective cohort study, patients with epithelial OC completed a food frequency questionnaire at diagnosis and 12 months post-diagnosis, and were followed from 2015 to 2023. Dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) were calculated based on specific antioxidant nutrients. We examined the associations of pre-diagnosis, post-diagnosis, and changes from pre-diagnosis to post-diagnosis in TAC, CDAI, and representative antioxidant nutrients with overall survival (OS) among patients with OC. Multivariable Cox proportional-hazards models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI). Dose–response relationships were evaluated by restricted cubic splines. Results Among the total 560 patients with OC, there were 211 (37.68%) deaths during a median follow-up of 44.40 (interquartile range: 26.97–61.37) months. High pre-diagnosis TAC (HR = 0.58; 95% CI 0.38–0.8) and vitamin C intake (HRT3 vs. T1 = 0.36; 95% CI 0.21–0.61), and post-diagnosis TAC (HR = 0.57; 95% CI 0.37–0.8), CDAI (HR = 0.57; 95% CI 0.33–0.9), and β-carotene intake (HRT3 vs. T1 = 0.55; 95% CI 0.32–0.97) were significantly associated with improved OS. Compared to patients with constantly low pre- and post-diagnosis TAC and CDAI, those with consistently higher TAC (HRMedium-Medium vs. Low-Low = 0.53; 95% CI 0.29–0.97; HRHigh-High vs. Low-Low = 0.40; 95% CI 0.16–0.94) and CDAI (HRHigh-High vs. Low-Low = 0.33; 95% CI 0.12–0.88) experienced better OS. Conclusion High pre- and post-diagnosis TAC, and post-diagnosis CDAI were associated with improved OC survival, suggesting that consistent high-intake of antioxidant-rich food may be beneficial for the prognosis of OC. |
| format | Article |
| id | doaj-art-b30d07ab32a448adb81e9d363c367cdd |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | Journal of Translational Medicine |
| spelling | doaj-art-b30d07ab32a448adb81e9d363c367cdd2025-02-02T12:40:20ZengBMCJournal of Translational Medicine1479-58762025-01-0123111410.1186/s12967-024-06041-6Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort studyDong-Dong Wang0Ming-Qian Jia1He-Li Xu2Yu Li3Jia-Xin Liu4Jia-Cheng Liu5Jia-Nan Sun6Fan Cao7Lang Wu8Fang-Hua Liu9Yi-Zi Li10Yi-Fan Wei11Xiao-Ying Li12Qian Xiao13Song Gao14Dong-Hui Huang15Tao Zhang16Ting-Ting Gong17Qi-Jun Wu18Department of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Epidemiology, School of Public Health, China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityCancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at ManoaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Pediatric, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityAbstract Background The evidence on the relationship of dietary antioxidant nutrients with the survival of ovarian cancer (OC) remains scarce. Objective This study aimed to investigate these associations in a prospective cohort of Chinese patients with OC. Methods In this prospective cohort study, patients with epithelial OC completed a food frequency questionnaire at diagnosis and 12 months post-diagnosis, and were followed from 2015 to 2023. Dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) were calculated based on specific antioxidant nutrients. We examined the associations of pre-diagnosis, post-diagnosis, and changes from pre-diagnosis to post-diagnosis in TAC, CDAI, and representative antioxidant nutrients with overall survival (OS) among patients with OC. Multivariable Cox proportional-hazards models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI). Dose–response relationships were evaluated by restricted cubic splines. Results Among the total 560 patients with OC, there were 211 (37.68%) deaths during a median follow-up of 44.40 (interquartile range: 26.97–61.37) months. High pre-diagnosis TAC (HR = 0.58; 95% CI 0.38–0.8) and vitamin C intake (HRT3 vs. T1 = 0.36; 95% CI 0.21–0.61), and post-diagnosis TAC (HR = 0.57; 95% CI 0.37–0.8), CDAI (HR = 0.57; 95% CI 0.33–0.9), and β-carotene intake (HRT3 vs. T1 = 0.55; 95% CI 0.32–0.97) were significantly associated with improved OS. Compared to patients with constantly low pre- and post-diagnosis TAC and CDAI, those with consistently higher TAC (HRMedium-Medium vs. Low-Low = 0.53; 95% CI 0.29–0.97; HRHigh-High vs. Low-Low = 0.40; 95% CI 0.16–0.94) and CDAI (HRHigh-High vs. Low-Low = 0.33; 95% CI 0.12–0.88) experienced better OS. Conclusion High pre- and post-diagnosis TAC, and post-diagnosis CDAI were associated with improved OC survival, suggesting that consistent high-intake of antioxidant-rich food may be beneficial for the prognosis of OC.https://doi.org/10.1186/s12967-024-06041-6Cohort studyComposite dietary antioxidant indexDietary total antioxidant capacityOvarian cancerSurvival |
| spellingShingle | Dong-Dong Wang Ming-Qian Jia He-Li Xu Yu Li Jia-Xin Liu Jia-Cheng Liu Jia-Nan Sun Fan Cao Lang Wu Fang-Hua Liu Yi-Zi Li Yi-Fan Wei Xiao-Ying Li Qian Xiao Song Gao Dong-Hui Huang Tao Zhang Ting-Ting Gong Qi-Jun Wu Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study Journal of Translational Medicine Cohort study Composite dietary antioxidant index Dietary total antioxidant capacity Ovarian cancer Survival |
| title | Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study |
| title_full | Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study |
| title_fullStr | Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study |
| title_full_unstemmed | Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study |
| title_short | Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study |
| title_sort | association of pre and post diagnosis dietary total antioxidant capacity tac and composite dietary antioxidant index cdai with overall survival in patients with ovarian cancer a prospective cohort study |
| topic | Cohort study Composite dietary antioxidant index Dietary total antioxidant capacity Ovarian cancer Survival |
| url | https://doi.org/10.1186/s12967-024-06041-6 |
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