Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition
Intrauterine growth restriction (IUGR) predisposes to obesity and adipose dysfunction. We previously demonstrated IUGR-induced increased visceral adipose deposition and dysregulated expression of peroxisome proliferator activated receptor-γ2 (PPARγ2) in male adolescent rats, prior to the onset of ob...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2013/312153 |
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| author | Heidi N. Bagley Yan Wang Michael S. Campbell Xing Yu Robert H. Lane Lisa A. Joss-Moore |
| author_facet | Heidi N. Bagley Yan Wang Michael S. Campbell Xing Yu Robert H. Lane Lisa A. Joss-Moore |
| author_sort | Heidi N. Bagley |
| collection | DOAJ |
| description | Intrauterine growth restriction (IUGR) predisposes to obesity and adipose dysfunction. We previously demonstrated IUGR-induced increased visceral adipose deposition and dysregulated expression of peroxisome proliferator activated receptor-γ2 (PPARγ2) in male adolescent rats, prior to the onset of obesity. In other studies, activation of PPARγ increases subcutaneous adiponectin expression and normalizes visceral adipose deposition. We hypothesized that maternal supplementation with docosahexaenoic acid (DHA), a PPARγ agonist, would normalize IUGR adipose deposition in association with increased PPARγ, adiponectin, and adiponectin receptor expression in subcutaneous adipose. To test these hypotheses, we used a well-characterized model of uteroplacental-insufficiency-(UPI-) induced IUGR in the rat with maternal DHA supplementation. Our primary findings were that maternal DHA supplementation during rat pregnancy and lactation (1) normalizes IUGR-induced changes in adipose deposition and visceral PPARγ expression in male rats and (2) increases serum adiponectin, as well as adipose expression of adiponectin and adiponectin receptors in former IUGR rats. Our novel findings suggest that maternal DHA supplementation may normalize adipose dysfunction and promote adiponectin-induced improvements in metabolic function in IUGR. |
| format | Article |
| id | doaj-art-b3020abc24a94f23976dbd4a330cb3a5 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-b3020abc24a94f23976dbd4a330cb3a52025-02-03T05:46:15ZengWileyJournal of Obesity2090-07082090-07162013-01-01201310.1155/2013/312153312153Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose DepositionHeidi N. Bagley0Yan Wang1Michael S. Campbell2Xing Yu3Robert H. Lane4Lisa A. Joss-Moore5Division of Nutrition, University of Utah, Salt Lake City, UT 84158, USADepartment of Pediatrics, University of Utah, Salt Lake City, UT 84158, USADivision of Nutrition, University of Utah, Salt Lake City, UT 84158, USADepartment of Pediatrics, University of Utah, Salt Lake City, UT 84158, USADepartment of Pediatrics, University of Utah, Salt Lake City, UT 84158, USADepartment of Pediatrics, University of Utah, Salt Lake City, UT 84158, USAIntrauterine growth restriction (IUGR) predisposes to obesity and adipose dysfunction. We previously demonstrated IUGR-induced increased visceral adipose deposition and dysregulated expression of peroxisome proliferator activated receptor-γ2 (PPARγ2) in male adolescent rats, prior to the onset of obesity. In other studies, activation of PPARγ increases subcutaneous adiponectin expression and normalizes visceral adipose deposition. We hypothesized that maternal supplementation with docosahexaenoic acid (DHA), a PPARγ agonist, would normalize IUGR adipose deposition in association with increased PPARγ, adiponectin, and adiponectin receptor expression in subcutaneous adipose. To test these hypotheses, we used a well-characterized model of uteroplacental-insufficiency-(UPI-) induced IUGR in the rat with maternal DHA supplementation. Our primary findings were that maternal DHA supplementation during rat pregnancy and lactation (1) normalizes IUGR-induced changes in adipose deposition and visceral PPARγ expression in male rats and (2) increases serum adiponectin, as well as adipose expression of adiponectin and adiponectin receptors in former IUGR rats. Our novel findings suggest that maternal DHA supplementation may normalize adipose dysfunction and promote adiponectin-induced improvements in metabolic function in IUGR.http://dx.doi.org/10.1155/2013/312153 |
| spellingShingle | Heidi N. Bagley Yan Wang Michael S. Campbell Xing Yu Robert H. Lane Lisa A. Joss-Moore Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition Journal of Obesity |
| title | Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition |
| title_full | Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition |
| title_fullStr | Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition |
| title_full_unstemmed | Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition |
| title_short | Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition |
| title_sort | maternal docosahexaenoic acid increases adiponectin and normalizes iugr induced changes in rat adipose deposition |
| url | http://dx.doi.org/10.1155/2013/312153 |
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