Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age

Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age

Abstract Variations in immune-cell fractions can confound or hamper interpretation of DNAm-based biomarkers in blood. Although cell-type deconvolution can address this challenge for cord and adult blood, currently there is no method applicable to blood from other age groups, including infants and ch...

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Bibliographic Details
Main Authors: Xiaolong Guo, Mahnoor Sulaiman, Alexander Neumann, Shijie C. Zheng, Charlotte A.M. Cecil, Andrew E. Teschendorff, Bastiaan T. Heijmans
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Medicine
Subjects:
Immune system
Cord blood
DNA methylation
EWAS
Cell-type deconvolution
Online Access:https://doi.org/10.1186/s13073-025-01489-7
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