Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice
The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the dorsal lateral geniculate nucleus (dLGN) of thalamus is also sensitive to altered...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/426437 |
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| author | Thomas E. Krahe Tania A. Seabrook Ching-Kang J. Chen Michael A. Fox William Guido |
| author_facet | Thomas E. Krahe Tania A. Seabrook Ching-Kang J. Chen Michael A. Fox William Guido |
| author_sort | Thomas E. Krahe |
| collection | DOAJ |
| description | The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the dorsal lateral geniculate nucleus (dLGN) of thalamus is also sensitive to altered sensory activity. DR disrupts retinogeniculate synaptic strength and pruning in mice, but only when DR starts one week after eye opening (delayed DR, DDR) and not after chronic DR (CDR) from birth. While DR upregulates CREB in visual cortex, whether it also modulates this pathway in dLGN remains unknown. Here we investigate the role of CREB in the dLGN of mice that were CDR or DDR using western blot and immunofluorescence. Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR. These findings are consistent with the proposal that DR up-regulates the CREB pathway in response to decreased visual drive. |
| format | Article |
| id | doaj-art-b2eb700e7f07416aad2b33854e0df6e9 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b2eb700e7f07416aad2b33854e0df6e92025-02-03T00:59:55ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/426437426437Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared MiceThomas E. Krahe0Tania A. Seabrook1Ching-Kang J. Chen2Michael A. Fox3William Guido4Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, 1101 E. Marshall Street, Richmond, VA 23298, USADepartment of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, 1101 E. Marshall Street, Richmond, VA 23298, USADepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USADepartment of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, 1101 E. Marshall Street, Richmond, VA 23298, USADepartment of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, 1101 E. Marshall Street, Richmond, VA 23298, USAThe cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the dorsal lateral geniculate nucleus (dLGN) of thalamus is also sensitive to altered sensory activity. DR disrupts retinogeniculate synaptic strength and pruning in mice, but only when DR starts one week after eye opening (delayed DR, DDR) and not after chronic DR (CDR) from birth. While DR upregulates CREB in visual cortex, whether it also modulates this pathway in dLGN remains unknown. Here we investigate the role of CREB in the dLGN of mice that were CDR or DDR using western blot and immunofluorescence. Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR. These findings are consistent with the proposal that DR up-regulates the CREB pathway in response to decreased visual drive.http://dx.doi.org/10.1155/2012/426437 |
| spellingShingle | Thomas E. Krahe Tania A. Seabrook Ching-Kang J. Chen Michael A. Fox William Guido Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice Neural Plasticity |
| title | Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice |
| title_full | Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice |
| title_fullStr | Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice |
| title_full_unstemmed | Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice |
| title_short | Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice |
| title_sort | modulation of creb in the dorsal lateral geniculate nucleus of dark reared mice |
| url | http://dx.doi.org/10.1155/2012/426437 |
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