Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus
Circadian rhythm disturbances are a common symptom among individuals with mood disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms. The SCN consists of self-sustaining oscillators and receives pho...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/1504507 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559093765636096 |
|---|---|
| author | Chelsea A. Vadnie Colleen A. McClung |
| author_facet | Chelsea A. Vadnie Colleen A. McClung |
| author_sort | Chelsea A. Vadnie |
| collection | DOAJ |
| description | Circadian rhythm disturbances are a common symptom among individuals with mood disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms. The SCN consists of self-sustaining oscillators and receives photic and nonphotic cues, which entrain the SCN to the external environment. In turn, through synaptic and hormonal mechanisms, the SCN can drive and synchronize circadian rhythms in extra-SCN brain regions and peripheral tissues. Thus, genetic or environmental perturbations of SCN rhythms could disrupt brain regions more closely related to mood regulation and cause mood disturbances. Here, we review clinical and preclinical studies that provide evidence both for and against a causal role for the SCN in mood disorders. |
| format | Article |
| id | doaj-art-b2cb33b79c3c43b788854537537b1d3e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b2cb33b79c3c43b788854537537b1d3e2025-02-03T01:30:55ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/15045071504507Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic NucleusChelsea A. Vadnie0Colleen A. McClung1Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, PA, USADepartment of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, PA, USACircadian rhythm disturbances are a common symptom among individuals with mood disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms. The SCN consists of self-sustaining oscillators and receives photic and nonphotic cues, which entrain the SCN to the external environment. In turn, through synaptic and hormonal mechanisms, the SCN can drive and synchronize circadian rhythms in extra-SCN brain regions and peripheral tissues. Thus, genetic or environmental perturbations of SCN rhythms could disrupt brain regions more closely related to mood regulation and cause mood disturbances. Here, we review clinical and preclinical studies that provide evidence both for and against a causal role for the SCN in mood disorders.http://dx.doi.org/10.1155/2017/1504507 |
| spellingShingle | Chelsea A. Vadnie Colleen A. McClung Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus Neural Plasticity |
| title | Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus |
| title_full | Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus |
| title_fullStr | Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus |
| title_full_unstemmed | Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus |
| title_short | Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus |
| title_sort | circadian rhythm disturbances in mood disorders insights into the role of the suprachiasmatic nucleus |
| url | http://dx.doi.org/10.1155/2017/1504507 |
| work_keys_str_mv | AT chelseaavadnie circadianrhythmdisturbancesinmooddisordersinsightsintotheroleofthesuprachiasmaticnucleus AT colleenamcclung circadianrhythmdisturbancesinmooddisordersinsightsintotheroleofthesuprachiasmaticnucleus |