Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy
Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-reactivity with AG antigen and thus place patients at risk for allergic and even anaphylactic reacti...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2020/5282843 |
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| _version_ | 1832566155317870592 |
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| author | Sohab S. Radwan Gauravpal Gill Amre Ghazzal Awais Malik Christopher Barnett |
| author_facet | Sohab S. Radwan Gauravpal Gill Amre Ghazzal Awais Malik Christopher Barnett |
| author_sort | Sohab S. Radwan |
| collection | DOAJ |
| description | Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-reactivity with AG antigen and thus place patients at risk for allergic and even anaphylactic reactions. This is especially important in patients with myocardial infarction (MI) and mechanical circulatory support, such as a left ventricular assist device (LVAD), since anticoagulation is immediately required. Therefore, individualized assessment and preoperative planning is needed regarding the use of heparin vs. nonheparinoid products in such a population. |
| format | Article |
| id | doaj-art-b2c17b0ddeed48f5ab9e88fba2363cfb |
| institution | Kabale University |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-b2c17b0ddeed48f5ab9e88fba2363cfb2025-02-03T01:05:00ZengWileyCase Reports in Cardiology2090-64042090-64122020-01-01202010.1155/2020/52828435282843Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal AllergySohab S. Radwan0Gauravpal Gill1Amre Ghazzal2Awais Malik3Christopher Barnett4MedStar Washington Hospital Center, Washington, DC, USAMedStar Washington Hospital Center, Washington, DC, USAMedStar Washington Hospital Center, Washington, DC, USAMedStar Georgetown University Hospital, Washington, DC, USAMedStar Washington Hospital Center, Washington, DC, USAAlpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-reactivity with AG antigen and thus place patients at risk for allergic and even anaphylactic reactions. This is especially important in patients with myocardial infarction (MI) and mechanical circulatory support, such as a left ventricular assist device (LVAD), since anticoagulation is immediately required. Therefore, individualized assessment and preoperative planning is needed regarding the use of heparin vs. nonheparinoid products in such a population.http://dx.doi.org/10.1155/2020/5282843 |
| spellingShingle | Sohab S. Radwan Gauravpal Gill Amre Ghazzal Awais Malik Christopher Barnett Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy Case Reports in Cardiology |
| title | Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy |
| title_full | Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy |
| title_fullStr | Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy |
| title_full_unstemmed | Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy |
| title_short | Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy |
| title_sort | plaque rupture induced myocardial infarction and mechanical circulatory support in alpha gal allergy |
| url | http://dx.doi.org/10.1155/2020/5282843 |
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