Two Imported Malaria Cases with Delayed Response to Treatment in Hatay
The study presents two imported malaria cases with a history of travel to malaria-endemic areas and replied late response to treatment. In the blood preparations of the first case, dot-shaped nucleus structures were identified in the erythrocytes, which looked different from the classical erythrocyt...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2024-12-01
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| Series: | Türkiye Parazitoloji Dergisi |
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| Online Access: | https://www.turkiyeparazitolderg.org/articles/two-imported-malaria-cases-with-delayed-response-to-treatment-in-hatay/doi/tpd.galenos.2024.25633 |
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| author | Tuğba Kaya Mehmet Çabalak Gülnaz Çulha Ceren Ünal |
| author_facet | Tuğba Kaya Mehmet Çabalak Gülnaz Çulha Ceren Ünal |
| author_sort | Tuğba Kaya |
| collection | DOAJ |
| description | The study presents two imported malaria cases with a history of travel to malaria-endemic areas and replied late response to treatment. In the blood preparations of the first case, dot-shaped nucleus structures were identified in the erythrocytes, which looked different from the classical erythrocytic forms. In the SD-Pf/Pan test, bands were obtained for both P.f and Pan; while in the SD-Pf/Pv test, a band was obtained for P.f. The P. falciparum18S rRNA gene was detected using real-time polymerase chain reaction. Artemether-lumefantrine treatment protocol was started. Due to deterioration in general condition on the third day, artemether-lumefantrine treatment was extended to six days, and primaquine phosphate was added. Discharge was on the 16th day of treatment. In the second case, young trophozoites were identified in blood smears. Bands in P.f were obtained in both the SD-Pf/Pan and SD-Pf/Pv tests. Artemether-lumefantrine treatment protocol was started. On the third day of treatment, banana-like gametocytes were observed in blood smears. The patient was discharged at his own request and two days later, upon follow-up, gametocytes were still observed in blood smears. Artemether-lumefantrine treatment was restarted. Gametocytes continued to be observed in the following days. Primaquine phosphate was added to the treatment protocol. The patient was discharged after a 3-week follow-up. The study is presented to draw attention to the increasing cases of imported malaria in Hatay and the increase of malaria cases that respond late to treatment in recent years. |
| format | Article |
| id | doaj-art-b2bae000b7154561aafbc6f5c84aae10 |
| institution | Kabale University |
| issn | 1300-6320 2146-3077 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türkiye Parazitoloji Dergisi |
| spelling | doaj-art-b2bae000b7154561aafbc6f5c84aae102025-01-23T08:07:56ZengGalenos YayineviTürkiye Parazitoloji Dergisi1300-63202146-30772024-12-0148425626010.4274/tpd.galenos.2024.25633Two Imported Malaria Cases with Delayed Response to Treatment in HatayTuğba Kaya0https://orcid.org/0000-0001-7612-5414Mehmet Çabalak1https://orcid.org/0000-0003-1148-2247Gülnaz Çulha2https://orcid.org/0000-0003-1034-132XCeren Ünal3https://orcid.org/0009-0000-2191-4950Hatay Mustafa Kemal University Faculty of Medicine, Department of Parasitology, Hatay, TürkiyeHatay Mustafa Kemal University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Hatay, TürkiyeHatay Mustafa Kemal University Faculty of Medicine, Department of Parasitology, Hatay, TürkiyeHatay Mustafa Kemal University Faculty of Medicine, Department of Parasitology, Hatay, TürkiyeThe study presents two imported malaria cases with a history of travel to malaria-endemic areas and replied late response to treatment. In the blood preparations of the first case, dot-shaped nucleus structures were identified in the erythrocytes, which looked different from the classical erythrocytic forms. In the SD-Pf/Pan test, bands were obtained for both P.f and Pan; while in the SD-Pf/Pv test, a band was obtained for P.f. The P. falciparum18S rRNA gene was detected using real-time polymerase chain reaction. Artemether-lumefantrine treatment protocol was started. Due to deterioration in general condition on the third day, artemether-lumefantrine treatment was extended to six days, and primaquine phosphate was added. Discharge was on the 16th day of treatment. In the second case, young trophozoites were identified in blood smears. Bands in P.f were obtained in both the SD-Pf/Pan and SD-Pf/Pv tests. Artemether-lumefantrine treatment protocol was started. On the third day of treatment, banana-like gametocytes were observed in blood smears. The patient was discharged at his own request and two days later, upon follow-up, gametocytes were still observed in blood smears. Artemether-lumefantrine treatment was restarted. Gametocytes continued to be observed in the following days. Primaquine phosphate was added to the treatment protocol. The patient was discharged after a 3-week follow-up. The study is presented to draw attention to the increasing cases of imported malaria in Hatay and the increase of malaria cases that respond late to treatment in recent years.https://www.turkiyeparazitolderg.org/articles/two-imported-malaria-cases-with-delayed-response-to-treatment-in-hatay/doi/tpd.galenos.2024.25633imported malariaplasmodium falciparumhatay |
| spellingShingle | Tuğba Kaya Mehmet Çabalak Gülnaz Çulha Ceren Ünal Two Imported Malaria Cases with Delayed Response to Treatment in Hatay Türkiye Parazitoloji Dergisi imported malaria plasmodium falciparum hatay |
| title | Two Imported Malaria Cases with Delayed Response to Treatment in Hatay |
| title_full | Two Imported Malaria Cases with Delayed Response to Treatment in Hatay |
| title_fullStr | Two Imported Malaria Cases with Delayed Response to Treatment in Hatay |
| title_full_unstemmed | Two Imported Malaria Cases with Delayed Response to Treatment in Hatay |
| title_short | Two Imported Malaria Cases with Delayed Response to Treatment in Hatay |
| title_sort | two imported malaria cases with delayed response to treatment in hatay |
| topic | imported malaria plasmodium falciparum hatay |
| url | https://www.turkiyeparazitolderg.org/articles/two-imported-malaria-cases-with-delayed-response-to-treatment-in-hatay/doi/tpd.galenos.2024.25633 |
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