Emulating real-world GLP-1 efficacy in type 2 diabetes through causal learning and virtual patients.

Randomized controlled trials (RCTs) remain the benchmark for assessing treatment effects but are limited to phenotypically narrow populations by design. We introduce a novel generative artificial intelligence (AI) driven emulation method that infers effect size through virtual clinical trials, which...

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Bibliographic Details
Main Authors: Calum Robert MacLellan, Hristo Petkov, Conor McKeag, Feng Dong, David John Lowe, Roma Maguire, Sotiris Moschoyiannis, Jo Armes, Simon Skene, Alastair Finlinson, Christopher Sainsbury
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLOS Digital Health
Online Access:https://doi.org/10.1371/journal.pdig.0000927
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