Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents
Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of buclizine (BUCZ) based on the formation of precipitation, charge transfer complex and inner complex formation. Method A involves the precipitation, charge transfer complex formation of BUCZ with tannic...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/350754 |
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| author | V. Annapurna G. Jyothi A. V. Subbayamma B. B. V. Sailaja |
| author_facet | V. Annapurna G. Jyothi A. V. Subbayamma B. B. V. Sailaja |
| author_sort | V. Annapurna |
| collection | DOAJ |
| description | Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of buclizine (BUCZ) based on the formation of precipitation, charge transfer complex and inner complex formation. Method A involves the precipitation, charge transfer complex formation of BUCZ with tannic acid/ p-N-methyl aminophenol sulphate (PMAP)-Cr(VI), the complex formation with cobalt thiocyanate (CTC) in method B and inner complex formation of BUCZ with sodium nitroprusside hydroxylamine hydrochloride and sodium carbonate in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system Determination of BUCZ in bulk form and in pharmaceutical formulations were also incorporated. |
| format | Article |
| id | doaj-art-b2ab454ef8f948bfa375ea3e2d3f1257 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-b2ab454ef8f948bfa375ea3e2d3f12572025-02-03T01:24:18ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-01741523152910.1155/2010/350754Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic ReagentsV. Annapurna0G. Jyothi1A. V. Subbayamma2B. B. V. Sailaja3Department of Chemistry, St. Theresa’s College for Women, Eluru-534003, IndiaDepartment of Chemistry, St. Theresa’s College for Women, Eluru-534003, IndiaDepartment of Chemistry, St. Theresa’s College for Women, Eluru-534003, IndiaAndhra University, Visakhapatnam, Andhra Pradesh, IndiaSimple, accurate and reproducible UV spectrophotometric methods were established for the assay of buclizine (BUCZ) based on the formation of precipitation, charge transfer complex and inner complex formation. Method A involves the precipitation, charge transfer complex formation of BUCZ with tannic acid/ p-N-methyl aminophenol sulphate (PMAP)-Cr(VI), the complex formation with cobalt thiocyanate (CTC) in method B and inner complex formation of BUCZ with sodium nitroprusside hydroxylamine hydrochloride and sodium carbonate in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system Determination of BUCZ in bulk form and in pharmaceutical formulations were also incorporated.http://dx.doi.org/10.1155/2010/350754 |
| spellingShingle | V. Annapurna G. Jyothi A. V. Subbayamma B. B. V. Sailaja Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents E-Journal of Chemistry |
| title | Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents |
| title_full | Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents |
| title_fullStr | Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents |
| title_full_unstemmed | Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents |
| title_short | Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents |
| title_sort | spectrphotometric determination of buclizine as hydrochloride using various chromogenic reagents |
| url | http://dx.doi.org/10.1155/2010/350754 |
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