Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs
Abstract Background Clinical characteristics of cervical hydrated nucleus pulposus extrusion (HNPE) in dogs compared to other causes of cervical myelopathy are not well described. Hypothesis/Objectives To evaluate for clinical characteristics and mechanical ventilation likelihood associated with HNP...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.17284 |
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| author | Megan Lin Christopher X. Hong Mark Rishniw Emma S. Davies Jonathan H. Wood |
| author_facet | Megan Lin Christopher X. Hong Mark Rishniw Emma S. Davies Jonathan H. Wood |
| author_sort | Megan Lin |
| collection | DOAJ |
| description | Abstract Background Clinical characteristics of cervical hydrated nucleus pulposus extrusion (HNPE) in dogs compared to other causes of cervical myelopathy are not well described. Hypothesis/Objectives To evaluate for clinical characteristics and mechanical ventilation likelihood associated with HNPE compared to other causes of cervical myelopathy. Animals Three hundred seventy‐seven client‐owned dogs from 2010 to 2022. Cases included 46 HNPE, 192 IVDE (intervertebral disc extrusion), 30 FCEM (fibrocartilaginous embolic myelopathy), 66 CSM (cervical spondylomyelopathy), and 43 neoplasia. Methods Retrospective study with record review and bivariate analyses. Dogs with signs of cervical myelopathy and an MRI diagnosis of HNPE, IVDE, FCEM, CSM, or neoplasia were included. Results When compared to dogs with other cervical myelopathies, dogs with HNPE were more likely to be older and of lower weight (median age 10 vs 8 years, P < .001; median weight 9.1 vs 20.2 kg, P < .001), be nonambulatory (89% vs 54%, P < .001), have signs of central cord syndrome (35% vs 16%, P = .002), and have nonlateralizing signs of myelopathy (65% vs 48%, P = .029). When compared to dogs with IVDE, dogs with HNPE were more likely to present with lower pain scores (30% vs 15% nonpainful, P = .002), and require mechanical ventilation (4/46 HNPE, 2/192 IVDE; odds ratio [OR] 9.0, 95% confidence interval [CI] 1.6‐51.0). Conclusions and Clinical Importance Compared to dogs with other cervical myelopathies, dogs with HNPE have differences in clinical characteristics, presentation and likelihood of requiring mechanical ventilation. These differences are important to consider for case management. |
| format | Article |
| id | doaj-art-b29748c4cb9a49c9b3693283b44927af |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-b29748c4cb9a49c9b3693283b44927af2025-01-27T15:22:41ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-01-01391n/an/a10.1111/jvim.17284Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogsMegan Lin0Christopher X. Hong1Mark Rishniw2Emma S. Davies3Jonathan H. Wood4Department of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York USADepartment of Obstetrics and Gynecology University of Michigan Ann Arbor Michigan USADepartment of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York USADepartment of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York USADepartment of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York USAAbstract Background Clinical characteristics of cervical hydrated nucleus pulposus extrusion (HNPE) in dogs compared to other causes of cervical myelopathy are not well described. Hypothesis/Objectives To evaluate for clinical characteristics and mechanical ventilation likelihood associated with HNPE compared to other causes of cervical myelopathy. Animals Three hundred seventy‐seven client‐owned dogs from 2010 to 2022. Cases included 46 HNPE, 192 IVDE (intervertebral disc extrusion), 30 FCEM (fibrocartilaginous embolic myelopathy), 66 CSM (cervical spondylomyelopathy), and 43 neoplasia. Methods Retrospective study with record review and bivariate analyses. Dogs with signs of cervical myelopathy and an MRI diagnosis of HNPE, IVDE, FCEM, CSM, or neoplasia were included. Results When compared to dogs with other cervical myelopathies, dogs with HNPE were more likely to be older and of lower weight (median age 10 vs 8 years, P < .001; median weight 9.1 vs 20.2 kg, P < .001), be nonambulatory (89% vs 54%, P < .001), have signs of central cord syndrome (35% vs 16%, P = .002), and have nonlateralizing signs of myelopathy (65% vs 48%, P = .029). When compared to dogs with IVDE, dogs with HNPE were more likely to present with lower pain scores (30% vs 15% nonpainful, P = .002), and require mechanical ventilation (4/46 HNPE, 2/192 IVDE; odds ratio [OR] 9.0, 95% confidence interval [CI] 1.6‐51.0). Conclusions and Clinical Importance Compared to dogs with other cervical myelopathies, dogs with HNPE have differences in clinical characteristics, presentation and likelihood of requiring mechanical ventilation. These differences are important to consider for case management.https://doi.org/10.1111/jvim.17284central cord syndromecervical myelopathyhydrated nucleus pulposus extrusionmagnetic resonance imagingnonambulatorytetraparesis |
| spellingShingle | Megan Lin Christopher X. Hong Mark Rishniw Emma S. Davies Jonathan H. Wood Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs Journal of Veterinary Internal Medicine central cord syndrome cervical myelopathy hydrated nucleus pulposus extrusion magnetic resonance imaging nonambulatory tetraparesis |
| title | Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs |
| title_full | Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs |
| title_fullStr | Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs |
| title_full_unstemmed | Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs |
| title_short | Clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs |
| title_sort | clinical characteristics associated with cervical hydrated nucleus pulposus extrusion in dogs |
| topic | central cord syndrome cervical myelopathy hydrated nucleus pulposus extrusion magnetic resonance imaging nonambulatory tetraparesis |
| url | https://doi.org/10.1111/jvim.17284 |
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