Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression
Renal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy. Despite monozygosity, there is a possibility of discordant protein presentatio...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2018/9842893 |
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| _version_ | 1832552587593777152 |
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| author | Idris Yakubu Abdolreza Haririan Stephen Bartlett Tracy Sparkes |
| author_facet | Idris Yakubu Abdolreza Haririan Stephen Bartlett Tracy Sparkes |
| author_sort | Idris Yakubu |
| collection | DOAJ |
| description | Renal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy. Despite monozygosity, there is a possibility of discordant protein presentation in identical twins that could trigger alloimmune response and lead to graft injury. Therefore, the optimal immunosuppression regimen in this patient population is unknown, and the safety of immunosuppression withdrawal remains controversial. Herein, we describe two patients who underwent successful renal transplantation from monozygotic identical twin donors. Monozygosity was determined using short tandem repeat (STR) analysis. All immunosuppression was successfully discontinued at 2 days and 3 weeks, respectively, after transplantation. Both patients are alive with functioning renal grafts at 1 year and 5 years after transplant, respectively. These two cases suggest that immunosuppression can be withdrawn safely and rapidly in select monozygous identical twin renal transplant recipients. |
| format | Article |
| id | doaj-art-b2804eae93764307a049a627c56339d0 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-b2804eae93764307a049a627c56339d02025-02-03T05:58:18ZengWileyCase Reports in Transplantation2090-69432090-69512018-01-01201810.1155/2018/98428939842893Successful Renal Transplantation between Identical Twins with Very Brief ImmunosuppressionIdris Yakubu0Abdolreza Haririan1Stephen Bartlett2Tracy Sparkes3Pharmacy, University of Maryland Medical Center, Baltimore, MD, USAUniversity of Maryland School of Medicine, Baltimore, MD, USAUniversity of Maryland School of Medicine, Baltimore, MD, USAPharmacy, University of Maryland Medical Center, Baltimore, MD, USARenal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy. Despite monozygosity, there is a possibility of discordant protein presentation in identical twins that could trigger alloimmune response and lead to graft injury. Therefore, the optimal immunosuppression regimen in this patient population is unknown, and the safety of immunosuppression withdrawal remains controversial. Herein, we describe two patients who underwent successful renal transplantation from monozygotic identical twin donors. Monozygosity was determined using short tandem repeat (STR) analysis. All immunosuppression was successfully discontinued at 2 days and 3 weeks, respectively, after transplantation. Both patients are alive with functioning renal grafts at 1 year and 5 years after transplant, respectively. These two cases suggest that immunosuppression can be withdrawn safely and rapidly in select monozygous identical twin renal transplant recipients.http://dx.doi.org/10.1155/2018/9842893 |
| spellingShingle | Idris Yakubu Abdolreza Haririan Stephen Bartlett Tracy Sparkes Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression Case Reports in Transplantation |
| title | Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression |
| title_full | Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression |
| title_fullStr | Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression |
| title_full_unstemmed | Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression |
| title_short | Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression |
| title_sort | successful renal transplantation between identical twins with very brief immunosuppression |
| url | http://dx.doi.org/10.1155/2018/9842893 |
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