Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus
Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K+ channels (KATP) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side e...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/530274 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548146055479296 |
|---|---|
| author | Danish Ahmed Manju Sharma |
| author_facet | Danish Ahmed Manju Sharma |
| author_sort | Danish Ahmed |
| collection | DOAJ |
| description | Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K+ channels (KATP) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side effects such as hypoglycaemia and cardiovascular adverse events. CDK5 is a serine/threonine protein kinase, which forms active complexes with p35 or p39 found principally in neurons and in pancreatic β cells. Pieces of evidence from recent studies recommend the vital role of CDK5 in physiological functions in nonneuronal cells such as glucose-stimulated insulin secretion in pancreatic cells. Inhibition of CDK5 averts the decrease of insulin gene expression through the inhibition of nuclear translocation of PDX-1 which is a transcription factor for the insulin gene. The present pieces of evidence designate that CDK5 might be a potential drug target for the regulation of glucose-stimulated insulin secretion in the treatment of diabetes mellitus. |
| format | Article |
| id | doaj-art-b252385d8b0e42c480e347071e41f876 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b252385d8b0e42c480e347071e41f8762025-02-03T06:42:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/530274530274Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes MellitusDanish Ahmed0Manju Sharma1Department of Pharmaceutical Sciences, Faculty of Health, Medical Sciences, Indigenous and Alternative Systems of Medicine, Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS), Allahabad 211007, IndiaDepartment of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, IndiaPresent therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K+ channels (KATP) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side effects such as hypoglycaemia and cardiovascular adverse events. CDK5 is a serine/threonine protein kinase, which forms active complexes with p35 or p39 found principally in neurons and in pancreatic β cells. Pieces of evidence from recent studies recommend the vital role of CDK5 in physiological functions in nonneuronal cells such as glucose-stimulated insulin secretion in pancreatic cells. Inhibition of CDK5 averts the decrease of insulin gene expression through the inhibition of nuclear translocation of PDX-1 which is a transcription factor for the insulin gene. The present pieces of evidence designate that CDK5 might be a potential drug target for the regulation of glucose-stimulated insulin secretion in the treatment of diabetes mellitus.http://dx.doi.org/10.1155/2011/530274 |
| spellingShingle | Danish Ahmed Manju Sharma Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus International Journal of Endocrinology |
| title | Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus |
| title_full | Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus |
| title_fullStr | Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus |
| title_full_unstemmed | Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus |
| title_short | Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus |
| title_sort | cyclin dependent kinase 5 p35 p39 a novel and imminent therapeutic target for diabetes mellitus |
| url | http://dx.doi.org/10.1155/2011/530274 |
| work_keys_str_mv | AT danishahmed cyclindependentkinase5p35p39anovelandimminenttherapeutictargetfordiabetesmellitus AT manjusharma cyclindependentkinase5p35p39anovelandimminenttherapeutictargetfordiabetesmellitus |