Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases
Research on mesenchymal stem cells (MSCs) starts from the earliest assumption that cells derived from the bone marrow have the ability to repair tissues. Several scientists have since documented the crucial role of bone marrow-derived MSCs (BM-MSCs) in processes such as embryonic bone and cartilage...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/5583994 |
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| _version_ | 1832558475495866368 |
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| author | Zhiping Wei Jintao Yuan Gaoying Wang Dickson Kofi Wiredu Ocansey Zhiwei Xu Fei Mao |
| author_facet | Zhiping Wei Jintao Yuan Gaoying Wang Dickson Kofi Wiredu Ocansey Zhiwei Xu Fei Mao |
| author_sort | Zhiping Wei |
| collection | DOAJ |
| description | Research on mesenchymal stem cells (MSCs) starts from the earliest assumption that cells derived from the bone marrow have the ability to repair tissues. Several scientists have since documented the crucial role of bone marrow-derived MSCs (BM-MSCs) in processes such as embryonic bone and cartilage formation, adult fracture and tissue repair, and immunomodulatory activities in therapeutic applications. In addition to BM-MSCs, several sources of MSCs have been reported to possess tissue repair and immunoregulatory abilities, making them potential treatment options for many diseases. Therefore, the therapeutic potential of MSCs in various diseases including autoimmune conditions has been explored. In addition to an imbalance of T cell subsets in most patients with autoimmune diseases, they also exhibit complex disease manifestations, overlapping symptoms among diseases, and difficult treatment. MSCs can regulate T cell subsets to restore their immune homeostasis toward disease resolution in autoimmune conditions. This review summarizes the role of MSCs in relieving autoimmune diseases via the regulation of T cell phenotypes. |
| format | Article |
| id | doaj-art-b243e66866544dd1ba319e52abb2a96c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b243e66866544dd1ba319e52abb2a96c2025-02-03T01:32:22ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/55839945583994Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune DiseasesZhiping Wei0Jintao Yuan1Gaoying Wang2Dickson Kofi Wiredu Ocansey3Zhiwei Xu4Fei Mao5Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaThe People’s Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang, Jiangsu 212300, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, ChinaResearch on mesenchymal stem cells (MSCs) starts from the earliest assumption that cells derived from the bone marrow have the ability to repair tissues. Several scientists have since documented the crucial role of bone marrow-derived MSCs (BM-MSCs) in processes such as embryonic bone and cartilage formation, adult fracture and tissue repair, and immunomodulatory activities in therapeutic applications. In addition to BM-MSCs, several sources of MSCs have been reported to possess tissue repair and immunoregulatory abilities, making them potential treatment options for many diseases. Therefore, the therapeutic potential of MSCs in various diseases including autoimmune conditions has been explored. In addition to an imbalance of T cell subsets in most patients with autoimmune diseases, they also exhibit complex disease manifestations, overlapping symptoms among diseases, and difficult treatment. MSCs can regulate T cell subsets to restore their immune homeostasis toward disease resolution in autoimmune conditions. This review summarizes the role of MSCs in relieving autoimmune diseases via the regulation of T cell phenotypes.http://dx.doi.org/10.1155/2021/5583994 |
| spellingShingle | Zhiping Wei Jintao Yuan Gaoying Wang Dickson Kofi Wiredu Ocansey Zhiwei Xu Fei Mao Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases Stem Cells International |
| title | Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases |
| title_full | Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases |
| title_fullStr | Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases |
| title_full_unstemmed | Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases |
| title_short | Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases |
| title_sort | regulatory effect of mesenchymal stem cells on t cell phenotypes in autoimmune diseases |
| url | http://dx.doi.org/10.1155/2021/5583994 |
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