Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging proc...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/603672 |
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| author | Micol Tomaiuolo Cynthia Katche Haydee Viola Jorge H. Medina |
| author_facet | Micol Tomaiuolo Cynthia Katche Haydee Viola Jorge H. Medina |
| author_sort | Micol Tomaiuolo |
| collection | DOAJ |
| description | The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag. |
| format | Article |
| id | doaj-art-b23dd5668ddd46009804edb52a6fdba9 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b23dd5668ddd46009804edb52a6fdba92025-02-03T05:44:30ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/603672603672Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory StorageMicol Tomaiuolo0Cynthia Katche1Haydee Viola2Jorge H. Medina3Instituto de Biología Celular y Neurociencias “Dr. Eduardo De Robertis”, Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, ArgentinaInstituto de Biología Celular y Neurociencias “Dr. Eduardo De Robertis”, Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, ArgentinaInstituto de Biología Celular y Neurociencias “Dr. Eduardo De Robertis”, Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, ArgentinaInstituto de Biología Celular y Neurociencias “Dr. Eduardo De Robertis”, Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, ArgentinaThe synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag.http://dx.doi.org/10.1155/2015/603672 |
| spellingShingle | Micol Tomaiuolo Cynthia Katche Haydee Viola Jorge H. Medina Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage Neural Plasticity |
| title | Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage |
| title_full | Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage |
| title_fullStr | Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage |
| title_full_unstemmed | Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage |
| title_short | Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage |
| title_sort | evidence of maintenance tagging in the hippocampus for the persistence of long lasting memory storage |
| url | http://dx.doi.org/10.1155/2015/603672 |
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