Murine Leukemia Viruses: Objects and Organisms
Murine leukemia viruses (MLVs) are among the simplest retroviruses. Prototypical gammaretroviruses encode only the three polyproteins that will be used in the assembly of progeny virus particles. These are the Gag polyprotein, which is the structural protein of a retrovirus particle, the Pol protein...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2011/403419 |
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| _version_ | 1832567749902073856 |
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| author | Alan Rein |
| author_facet | Alan Rein |
| author_sort | Alan Rein |
| collection | DOAJ |
| description | Murine leukemia viruses (MLVs) are among the simplest retroviruses. Prototypical gammaretroviruses encode only the three polyproteins that will be used in the assembly of progeny virus particles. These are the Gag polyprotein, which is the structural protein of a retrovirus particle, the Pol protein, comprising the three retroviral enzymes—protease, which catalyzes the maturation of the particle, reverse transcriptase, which copies the viral RNA into DNA upon infection of a new host cell, and integrase, which inserts the DNA into the chromosomal DNA of the host cell, and the Env polyprotein, which induces the fusion of the viral membrane with that of the new host cell, initiating infection. In general, a productive MLV infection has no obvious effect upon host cells. Although gammaretroviral structure and replication follow the same broad outlines as those of other retroviruses, we point out a number of significant differences between different retroviral genera. |
| format | Article |
| id | doaj-art-b239b897d9b34e7ba54e80d93588ad19 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-b239b897d9b34e7ba54e80d93588ad192025-02-03T01:00:41ZengWileyAdvances in Virology1687-86391687-86472011-01-01201110.1155/2011/403419403419Murine Leukemia Viruses: Objects and OrganismsAlan Rein0HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, MD 21702, USAMurine leukemia viruses (MLVs) are among the simplest retroviruses. Prototypical gammaretroviruses encode only the three polyproteins that will be used in the assembly of progeny virus particles. These are the Gag polyprotein, which is the structural protein of a retrovirus particle, the Pol protein, comprising the three retroviral enzymes—protease, which catalyzes the maturation of the particle, reverse transcriptase, which copies the viral RNA into DNA upon infection of a new host cell, and integrase, which inserts the DNA into the chromosomal DNA of the host cell, and the Env polyprotein, which induces the fusion of the viral membrane with that of the new host cell, initiating infection. In general, a productive MLV infection has no obvious effect upon host cells. Although gammaretroviral structure and replication follow the same broad outlines as those of other retroviruses, we point out a number of significant differences between different retroviral genera.http://dx.doi.org/10.1155/2011/403419 |
| spellingShingle | Alan Rein Murine Leukemia Viruses: Objects and Organisms Advances in Virology |
| title | Murine Leukemia Viruses: Objects and Organisms |
| title_full | Murine Leukemia Viruses: Objects and Organisms |
| title_fullStr | Murine Leukemia Viruses: Objects and Organisms |
| title_full_unstemmed | Murine Leukemia Viruses: Objects and Organisms |
| title_short | Murine Leukemia Viruses: Objects and Organisms |
| title_sort | murine leukemia viruses objects and organisms |
| url | http://dx.doi.org/10.1155/2011/403419 |
| work_keys_str_mv | AT alanrein murineleukemiavirusesobjectsandorganisms |