Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells
Multiple myeloma (MM) is an incurable B cell neoplasia characterized by the accumulation of tumor plasma cells within the bone marrow (BM). As a consequence, bone osteolytic lesions develop in 80% of patients and remain even after complete disease remission. We and others had demonstrated that BM-de...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/4173578 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546966902407168 |
|---|---|
| author | Nicolas Espagnolle Benjamin Hebraud Jean-Gérard Descamps Mélanie Gadelorge Marie-Véronique Joubert Laura Do Souto Ferreira Murielle Roussel Anne Huynh Luc Sensébé Louis Casteilla Michel Attal Hervé Avet-Loiseau Frederic Deschaseaux Philippe Bourin Jill Corre |
| author_facet | Nicolas Espagnolle Benjamin Hebraud Jean-Gérard Descamps Mélanie Gadelorge Marie-Véronique Joubert Laura Do Souto Ferreira Murielle Roussel Anne Huynh Luc Sensébé Louis Casteilla Michel Attal Hervé Avet-Loiseau Frederic Deschaseaux Philippe Bourin Jill Corre |
| author_sort | Nicolas Espagnolle |
| collection | DOAJ |
| description | Multiple myeloma (MM) is an incurable B cell neoplasia characterized by the accumulation of tumor plasma cells within the bone marrow (BM). As a consequence, bone osteolytic lesions develop in 80% of patients and remain even after complete disease remission. We and others had demonstrated that BM-derived mesenchymal stromal cells (MSCs) are abnormal in MM and thus cannot be used for autologous treatment to repair bone damage. Adipose stromal cells (ASCs) represent an interesting alternative to MSCs for cellular therapy. Thus, in this study, we wondered whether they could be a good candidate in repairing MM bone lesions. For the first time, we present a transcriptomic, phenotypic, and functional comparison of ASCs from MM patients and healthy donors (HDs) relying on their autologous MSC counterparts. In contrast to MM MSCs, MM ASCs did not exhibit major abnormalities. However, the changes observed in MM ASCs and the supportive property of ASCs on MM cells question their putative and safety uses at an autologous or allogenic level. |
| format | Article |
| id | doaj-art-b236d90616004262ad97400f3a2e8850 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b236d90616004262ad97400f3a2e88502025-02-03T06:46:29ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/41735784173578Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal CellsNicolas Espagnolle0Benjamin Hebraud1Jean-Gérard Descamps2Mélanie Gadelorge3Marie-Véronique Joubert4Laura Do Souto Ferreira5Murielle Roussel6Anne Huynh7Luc Sensébé8Louis Casteilla9Michel Attal10Hervé Avet-Loiseau11Frederic Deschaseaux12Philippe Bourin13Jill Corre14STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceHematology Department, Institut Universitaire du Cancer, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceLaboratory for Genomics in Myeloma, Institut Universitaire du Cancer, Toulouse, FranceLaboratory for Genomics in Myeloma, Institut Universitaire du Cancer, Toulouse, FranceHematology Department, Institut Universitaire du Cancer, Toulouse, FranceHematology Department, Institut Universitaire du Cancer, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceHematology Department, Institut Universitaire du Cancer, Toulouse, FranceLaboratory for Genomics in Myeloma, Institut Universitaire du Cancer, Toulouse, FranceSTROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS, Toulouse, FranceCell-Easy, Centre Pierre Potier, 31106 Toulouse Cedex 1, FranceLaboratory for Genomics in Myeloma, Institut Universitaire du Cancer, Toulouse, FranceMultiple myeloma (MM) is an incurable B cell neoplasia characterized by the accumulation of tumor plasma cells within the bone marrow (BM). As a consequence, bone osteolytic lesions develop in 80% of patients and remain even after complete disease remission. We and others had demonstrated that BM-derived mesenchymal stromal cells (MSCs) are abnormal in MM and thus cannot be used for autologous treatment to repair bone damage. Adipose stromal cells (ASCs) represent an interesting alternative to MSCs for cellular therapy. Thus, in this study, we wondered whether they could be a good candidate in repairing MM bone lesions. For the first time, we present a transcriptomic, phenotypic, and functional comparison of ASCs from MM patients and healthy donors (HDs) relying on their autologous MSC counterparts. In contrast to MM MSCs, MM ASCs did not exhibit major abnormalities. However, the changes observed in MM ASCs and the supportive property of ASCs on MM cells question their putative and safety uses at an autologous or allogenic level.http://dx.doi.org/10.1155/2020/4173578 |
| spellingShingle | Nicolas Espagnolle Benjamin Hebraud Jean-Gérard Descamps Mélanie Gadelorge Marie-Véronique Joubert Laura Do Souto Ferreira Murielle Roussel Anne Huynh Luc Sensébé Louis Casteilla Michel Attal Hervé Avet-Loiseau Frederic Deschaseaux Philippe Bourin Jill Corre Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells Stem Cells International |
| title | Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells |
| title_full | Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells |
| title_fullStr | Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells |
| title_full_unstemmed | Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells |
| title_short | Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells |
| title_sort | functional comparison between healthy and multiple myeloma adipose stromal cells |
| url | http://dx.doi.org/10.1155/2020/4173578 |
| work_keys_str_mv | AT nicolasespagnolle functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT benjaminhebraud functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT jeangerarddescamps functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT melaniegadelorge functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT marieveroniquejoubert functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT lauradosoutoferreira functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT murielleroussel functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT annehuynh functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT lucsensebe functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT louiscasteilla functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT michelattal functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT herveavetloiseau functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT fredericdeschaseaux functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT philippebourin functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells AT jillcorre functionalcomparisonbetweenhealthyandmultiplemyelomaadiposestromalcells |