Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes
Pediatric autoimmune hepatitis (AIH) patients present hypergammaglobulinemia, periportal CD8+ cytotoxic T cell infiltration, and cirrhosis. Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1. We previously detected increased IgE serum levels and sought to...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/679813 |
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| author | Léa Campos de Oliveira Anna Carla Goldberg Maria Lucia Carnevale Marin Karina Rosa Schneidwind Amanda Farage Frade Jorge Kalil Irene Kasue Miura Renata Pereira Sustovich Pugliese Vera Lucia Baggio Danesi Gilda Porta |
| author_facet | Léa Campos de Oliveira Anna Carla Goldberg Maria Lucia Carnevale Marin Karina Rosa Schneidwind Amanda Farage Frade Jorge Kalil Irene Kasue Miura Renata Pereira Sustovich Pugliese Vera Lucia Baggio Danesi Gilda Porta |
| author_sort | Léa Campos de Oliveira |
| collection | DOAJ |
| description | Pediatric autoimmune hepatitis (AIH) patients present hypergammaglobulinemia, periportal CD8+ cytotoxic T cell infiltration, and cirrhosis. Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1. We previously detected increased IgE serum levels and sought to compare clinical and histological features according to IgE levels in AIH (n=74, ages 1–14 years) patients. Additionally, we typed 117 patients and 227 controls for functional polymorphisms of IL4, IL13, IL5, and IL4RA genes involved in IgE switching and eosinophil maturation that might contribute to overall genetic susceptibility to AIH. Serum IgE levels were high in 55% of AIH-1, but only in 12% of AIH-2 (P=0.003) patients. Liver IgE was present in 91.3% of AIH-1 patients. The A alleles at both IL13 rs20541 and IL4RA rs1805011 were associated with AIH-1 (P=0.024, OR = 1.55 and P<0.0001, OR = 2.15, resp.). Furthermore, individuals presenting homozygosis for the A allele at IL4RA rs1805011 and HLA-DRB103∗ and/or 13∗ allele had sixfold greater risk to develop the disease (OR = 14.00, P<0.001). The novel association suggests an additional role for IgE-linked immune response genes in the pathogenesis of AIH. |
| format | Article |
| id | doaj-art-b231929c8b4f46a093fa3a7e5803d8db |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b231929c8b4f46a093fa3a7e5803d8db2025-02-03T06:42:14ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/679813679813Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated GenesLéa Campos de Oliveira0Anna Carla Goldberg1Maria Lucia Carnevale Marin2Karina Rosa Schneidwind3Amanda Farage Frade4Jorge Kalil5Irene Kasue Miura6Renata Pereira Sustovich Pugliese7Vera Lucia Baggio Danesi8Gilda Porta9Laboratório de Medicina Laboratorial (LIM03), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, BrazilHospital Israelita Albert Einstein, 05652-900 São Paulo, SP, BrazilLaboratório de Imunologia, Instituto do Coração (InCor), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, BrazilDepartamento de Hepatologia, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, BrazilDivisão de Alergia e Imunologia Clínica, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, BrazilInstituto de Investigação em Imunologia, Instituto Nacional de Ciência e Tecnologia, 05403-000 São Paulo, SP, BrazilDepartamento de Hepatologia, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, BrazilDepartamento de Hepatologia, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, BrazilDepartamento de Hepatologia, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, BrazilDepartamento de Hepatologia, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, BrazilPediatric autoimmune hepatitis (AIH) patients present hypergammaglobulinemia, periportal CD8+ cytotoxic T cell infiltration, and cirrhosis. Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1. We previously detected increased IgE serum levels and sought to compare clinical and histological features according to IgE levels in AIH (n=74, ages 1–14 years) patients. Additionally, we typed 117 patients and 227 controls for functional polymorphisms of IL4, IL13, IL5, and IL4RA genes involved in IgE switching and eosinophil maturation that might contribute to overall genetic susceptibility to AIH. Serum IgE levels were high in 55% of AIH-1, but only in 12% of AIH-2 (P=0.003) patients. Liver IgE was present in 91.3% of AIH-1 patients. The A alleles at both IL13 rs20541 and IL4RA rs1805011 were associated with AIH-1 (P=0.024, OR = 1.55 and P<0.0001, OR = 2.15, resp.). Furthermore, individuals presenting homozygosis for the A allele at IL4RA rs1805011 and HLA-DRB103∗ and/or 13∗ allele had sixfold greater risk to develop the disease (OR = 14.00, P<0.001). The novel association suggests an additional role for IgE-linked immune response genes in the pathogenesis of AIH.http://dx.doi.org/10.1155/2015/679813 |
| spellingShingle | Léa Campos de Oliveira Anna Carla Goldberg Maria Lucia Carnevale Marin Karina Rosa Schneidwind Amanda Farage Frade Jorge Kalil Irene Kasue Miura Renata Pereira Sustovich Pugliese Vera Lucia Baggio Danesi Gilda Porta Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes Journal of Immunology Research |
| title | Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes |
| title_full | Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes |
| title_fullStr | Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes |
| title_full_unstemmed | Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes |
| title_short | Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes |
| title_sort | autoimmune hepatitis in brazilian children ige and genetic polymorphisms in associated genes |
| url | http://dx.doi.org/10.1155/2015/679813 |
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