The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients
Abstract The objective of this study was to examine the association between serum tacrolimus trough levels and the detection of BK viruria in kidney transplant recipients. We conducted a retrospective study and included kidney transplant recipients who underwent BK viruria screening during 2018–2021...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86465-2 |
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| author | Napatsorn Kraivisitkul Kajohnsak Noppakun Chotiwit Sakuludomkan Supavit Jirawattanapong Siriaran Kwangsukstith Nahathai Dukaew Naruemon Suyayai Mingkwan Na Takuathung Nut Koonrungsesomboon |
| author_facet | Napatsorn Kraivisitkul Kajohnsak Noppakun Chotiwit Sakuludomkan Supavit Jirawattanapong Siriaran Kwangsukstith Nahathai Dukaew Naruemon Suyayai Mingkwan Na Takuathung Nut Koonrungsesomboon |
| author_sort | Napatsorn Kraivisitkul |
| collection | DOAJ |
| description | Abstract The objective of this study was to examine the association between serum tacrolimus trough levels and the detection of BK viruria in kidney transplant recipients. We conducted a retrospective study and included kidney transplant recipients who underwent BK viruria screening during 2018–2021. Serum tacrolimus trough levels, urine BK viral load, and potential risk factors were collected. Statistical analysis was performed to identify the association between the serum tacrolimus trough levels and the detection of BK virus in urine (defined as positive BK viruria), as well as to determine the cumulative incidence and risk factors for BK viruria. Out of 243 recipients, 76 had positive BK viruria. The average serum tacrolimus trough level was significantly higher among the positive BK viruria group compared to the BK viruria-negative group. High HLA mismatch was identified as a risk factor for BK viruria. Approximately half of the recipients with average serum tacrolimus trough levels exceeding 10 ng/mL would develop BK viruria early. This study found an association between the average serum tacrolimus trough level and the detection of BK viruria. High HLA mismatch and an average serum tacrolimus trough level exceeding 10 ng/mL should be regarded as a risk for BK viruria. |
| format | Article |
| id | doaj-art-b22ef11bec7c431f97fee595a4d9b8b2 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b22ef11bec7c431f97fee595a4d9b8b22025-01-26T12:28:05ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-86465-2The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipientsNapatsorn Kraivisitkul0Kajohnsak Noppakun1Chotiwit Sakuludomkan2Supavit Jirawattanapong3Siriaran Kwangsukstith4Nahathai Dukaew5Naruemon Suyayai6Mingkwan Na Takuathung7Nut Koonrungsesomboon8Faculty of Medicine, Chiang Mai UniversityDivision of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai UniversityDepartment of Pharmacology, Faculty of Medicine, Chiang Mai UniversityFaculty of Medicine, Chiang Mai UniversityFaculty of Medicine, Chiang Mai UniversityDepartment of Pharmacology, Faculty of Medicine, Chiang Mai UniversityTransplant and Dialysis Unit, Medical Nursing Division, Maharaj Nakorn Chiang Mai HospitalDepartment of Pharmacology, Faculty of Medicine, Chiang Mai UniversityDepartment of Pharmacology, Faculty of Medicine, Chiang Mai UniversityAbstract The objective of this study was to examine the association between serum tacrolimus trough levels and the detection of BK viruria in kidney transplant recipients. We conducted a retrospective study and included kidney transplant recipients who underwent BK viruria screening during 2018–2021. Serum tacrolimus trough levels, urine BK viral load, and potential risk factors were collected. Statistical analysis was performed to identify the association between the serum tacrolimus trough levels and the detection of BK virus in urine (defined as positive BK viruria), as well as to determine the cumulative incidence and risk factors for BK viruria. Out of 243 recipients, 76 had positive BK viruria. The average serum tacrolimus trough level was significantly higher among the positive BK viruria group compared to the BK viruria-negative group. High HLA mismatch was identified as a risk factor for BK viruria. Approximately half of the recipients with average serum tacrolimus trough levels exceeding 10 ng/mL would develop BK viruria early. This study found an association between the average serum tacrolimus trough level and the detection of BK viruria. High HLA mismatch and an average serum tacrolimus trough level exceeding 10 ng/mL should be regarded as a risk for BK viruria.https://doi.org/10.1038/s41598-025-86465-2BK viruriaBK virus nephropathyRisk factorsTherapeutic drug monitoringTacrolimus |
| spellingShingle | Napatsorn Kraivisitkul Kajohnsak Noppakun Chotiwit Sakuludomkan Supavit Jirawattanapong Siriaran Kwangsukstith Nahathai Dukaew Naruemon Suyayai Mingkwan Na Takuathung Nut Koonrungsesomboon The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients Scientific Reports BK viruria BK virus nephropathy Risk factors Therapeutic drug monitoring Tacrolimus |
| title | The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients |
| title_full | The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients |
| title_fullStr | The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients |
| title_full_unstemmed | The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients |
| title_short | The association between serum tacrolimus concentrations and BK viruria in kidney transplant recipients |
| title_sort | association between serum tacrolimus concentrations and bk viruria in kidney transplant recipients |
| topic | BK viruria BK virus nephropathy Risk factors Therapeutic drug monitoring Tacrolimus |
| url | https://doi.org/10.1038/s41598-025-86465-2 |
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