Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish Native
A 41-year-old Coast Salish female was initially diagnosed with typical features of classical adult celiac disease. Clinical and pathological features of primary biliary cirrhosis were also present, along with a familial history of insulin-dependent diabetes. Later, childhood celiac disease was detec...
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| Format: | Article |
| Language: | English |
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Wiley
1994-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1994/150426 |
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| _version_ | 1832556492435226624 |
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| author | Hugh J Freeman |
| author_facet | Hugh J Freeman |
| author_sort | Hugh J Freeman |
| collection | DOAJ |
| description | A 41-year-old Coast Salish female was initially diagnosed with typical features of classical adult celiac disease. Clinical and pathological features of primary biliary cirrhosis were also present, along with a familial history of insulin-dependent diabetes. Later, childhood celiac disease was detected in a male first-degree relative with diabetes. These patients are the first reported natives in Canada with celiac disease, a disorder believed to be genetically based but dependent on environmental factors for its clinical expression. The recognition of a ‘new’ disease in the setting of an aboriginal population may reflect geographical and climatic factors that permitted subsistence of this culturally complex food-gathering society up until most recent historical times, followed by adaptation of this society to European-based agricultural methods, particularly wheat cultivation. |
| format | Article |
| id | doaj-art-b22e8992566c441b82e10ab9e6fbcbd2 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-b22e8992566c441b82e10ab9e6fbcbd22025-02-03T05:45:16ZengWileyCanadian Journal of Gastroenterology0835-79001994-01-018210510710.1155/1994/150426Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish NativeHugh J Freeman0Department of Medicine (Gastroenterology), University Hospital and University of British Columbia, Vancouver, British Columbia, CanadaA 41-year-old Coast Salish female was initially diagnosed with typical features of classical adult celiac disease. Clinical and pathological features of primary biliary cirrhosis were also present, along with a familial history of insulin-dependent diabetes. Later, childhood celiac disease was detected in a male first-degree relative with diabetes. These patients are the first reported natives in Canada with celiac disease, a disorder believed to be genetically based but dependent on environmental factors for its clinical expression. The recognition of a ‘new’ disease in the setting of an aboriginal population may reflect geographical and climatic factors that permitted subsistence of this culturally complex food-gathering society up until most recent historical times, followed by adaptation of this society to European-based agricultural methods, particularly wheat cultivation.http://dx.doi.org/10.1155/1994/150426 |
| spellingShingle | Hugh J Freeman Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish Native Canadian Journal of Gastroenterology |
| title | Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish Native |
| title_full | Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish Native |
| title_fullStr | Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish Native |
| title_full_unstemmed | Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish Native |
| title_short | Celiac Disease Assocaited with Primary Biliary Cirrhosis in a Coast Salish Native |
| title_sort | celiac disease assocaited with primary biliary cirrhosis in a coast salish native |
| url | http://dx.doi.org/10.1155/1994/150426 |
| work_keys_str_mv | AT hughjfreeman celiacdiseaseassocaitedwithprimarybiliarycirrhosisinacoastsalishnative |