Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)
The most common cardiac tumors of heart muscle are rhabdomyomas, solitary or multiple benign tumors of striated muscle origin. While cardiac rhabdomyomas are well described in human medical literature, limited information depicting the occurrence of cardiac rhabdomyomas in veterinary species exists....
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Veterinary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/103279 |
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| author | G. Krafsur E. J. Ehrhart J. Ramos-Vara G. Mason F. Sarren B. Adams C. Hanns T. Spraker C. Duncan |
| author_facet | G. Krafsur E. J. Ehrhart J. Ramos-Vara G. Mason F. Sarren B. Adams C. Hanns T. Spraker C. Duncan |
| author_sort | G. Krafsur |
| collection | DOAJ |
| description | The most common cardiac tumors of heart muscle are rhabdomyomas, solitary or multiple benign tumors of striated muscle origin. While cardiac rhabdomyomas are well described in human medical literature, limited information depicting the occurrence of cardiac rhabdomyomas in veterinary species exists. A case of multiple firm white nonencapsulated nodules in the heart of a bearded seal is described. Microscopic findings included cytoplasmic vacuolization with formation of spider cells, glycogen vacuoles, and striated myofibrils. These cells expressed immunoreactivity for neuron-specific enolase and protein gene product 9.5, a marker for neuronal tissue and Purkinje fiber cells. Immunoreactivity for protein gene product 9.5 along with other microscopic findings substantiates Purkinje fiber cell origin of the cardiac rhabdomyoma in the bearded seal and use of the term purkinjeoma to describe this lesion. |
| format | Article |
| id | doaj-art-b2284d3ca3eb419bb0061913a60460e9 |
| institution | Kabale University |
| issn | 2090-7001 2090-701X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Veterinary Medicine |
| spelling | doaj-art-b2284d3ca3eb419bb0061913a60460e92025-02-03T01:30:34ZengWileyCase Reports in Veterinary Medicine2090-70012090-701X2014-01-01201410.1155/2014/103279103279Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus)G. Krafsur0E. J. Ehrhart1J. Ramos-Vara2G. Mason3F. Sarren4B. Adams5C. Hanns6T. Spraker7C. Duncan8CSU Veterinary Diagnostic Medicine Center, Fort Collins, CO, USACSU Veterinary Diagnostic Medicine Center, Fort Collins, CO, USAIndiana Animal Disease Diagnostic Laboratory and Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USACSU Veterinary Diagnostic Medicine Center, Fort Collins, CO, USANorth Slope Borough Department of Wildlife Management, Barrow, AK, USANorth Slope Borough Department of Wildlife Management, Barrow, AK, USANorth Slope Borough Department of Wildlife Management, Barrow, AK, USACSU Veterinary Diagnostic Medicine Center, Fort Collins, CO, USACSU Veterinary Diagnostic Medicine Center, Fort Collins, CO, USAThe most common cardiac tumors of heart muscle are rhabdomyomas, solitary or multiple benign tumors of striated muscle origin. While cardiac rhabdomyomas are well described in human medical literature, limited information depicting the occurrence of cardiac rhabdomyomas in veterinary species exists. A case of multiple firm white nonencapsulated nodules in the heart of a bearded seal is described. Microscopic findings included cytoplasmic vacuolization with formation of spider cells, glycogen vacuoles, and striated myofibrils. These cells expressed immunoreactivity for neuron-specific enolase and protein gene product 9.5, a marker for neuronal tissue and Purkinje fiber cells. Immunoreactivity for protein gene product 9.5 along with other microscopic findings substantiates Purkinje fiber cell origin of the cardiac rhabdomyoma in the bearded seal and use of the term purkinjeoma to describe this lesion.http://dx.doi.org/10.1155/2014/103279 |
| spellingShingle | G. Krafsur E. J. Ehrhart J. Ramos-Vara G. Mason F. Sarren B. Adams C. Hanns T. Spraker C. Duncan Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus) Case Reports in Veterinary Medicine |
| title | Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus) |
| title_full | Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus) |
| title_fullStr | Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus) |
| title_full_unstemmed | Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus) |
| title_short | Histomorphologic and Immunohistochemical Characterization of a Cardiac Purkinjeoma in a Bearded Seal (Erignathus barbatus) |
| title_sort | histomorphologic and immunohistochemical characterization of a cardiac purkinjeoma in a bearded seal erignathus barbatus |
| url | http://dx.doi.org/10.1155/2014/103279 |
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