Importância dos ensaios físico-químicos no controle de qualidade de vacinas
The National Immunization Program (NIP), established in 1973, is recognized nationally and internationally as one of the largest vaccination programs in the world, integrated into the Unified Health System (SUS). Over the years, the NIP has faced challenges in vaccine quality control, leading to sig...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2025-01-01
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| Series: | Química Nova |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422025000300313&lng=pt&tlng=pt |
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| author | Maria P. Blanco Cristiane Barata Silva Santos A. Vicentini Neto Lara M. Catarino Ozeias de Lima Leitão Elizabete P. Figuerêdo Mateus H. M. Neves Silvana C. Jacob Lisia M. G. dos Santos |
| author_facet | Maria P. Blanco Cristiane Barata Silva Santos A. Vicentini Neto Lara M. Catarino Ozeias de Lima Leitão Elizabete P. Figuerêdo Mateus H. M. Neves Silvana C. Jacob Lisia M. G. dos Santos |
| author_sort | Maria P. Blanco |
| collection | DOAJ |
| description | The National Immunization Program (NIP), established in 1973, is recognized nationally and internationally as one of the largest vaccination programs in the world, integrated into the Unified Health System (SUS). Over the years, the NIP has faced challenges in vaccine quality control, leading to significant evolution, especially since 1983 when the National Institute of Quality Control in Health (INCQS) centralized this control. INCQS conducts biological, microbiological, and physicochemical assays, such as pH, appearance, aluminum content, and thiomersal, the latter present in multidose vaccines as a preservative. Retrospective analysis of physicochemical assays reveals variations in analysis quantities, often correlated with specific vaccination campaigns. The introduction of new vaccines in the NIP, such as the pentavalent and inactivated polio vaccines, impacted quality control. Regarding the pH and appearance of vaccines, assays demonstrate improvements over time, including the adoption of more sensitive and specific techniques. The implementation of visual inspection aspect analysis as a preventive measure after occurrences of unsatisfactory lots underscores the commitment to vaccine safety. Public laboratories, like INCQS, play a crucial role in this process, ensuring the safety of immunobiological for the entire Brazilian population. The current challenge lies in the need to keep up with technological advancements to maintain vaccine quality. |
| format | Article |
| id | doaj-art-b220145357be46d79e61d602daf3036b |
| institution | Kabale University |
| issn | 1678-7064 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj-art-b220145357be46d79e61d602daf3036b2025-01-21T07:37:59ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642025-01-0148310.21577/0100-4042.20250082Importância dos ensaios físico-químicos no controle de qualidade de vacinasMaria P. BlancoCristiane Barata SilvaSantos A. Vicentini NetoLara M. CatarinoOzeias de Lima LeitãoElizabete P. FiguerêdoMateus H. M. NevesSilvana C. JacobLisia M. G. dos Santoshttps://orcid.org/0000-0002-0652-7538The National Immunization Program (NIP), established in 1973, is recognized nationally and internationally as one of the largest vaccination programs in the world, integrated into the Unified Health System (SUS). Over the years, the NIP has faced challenges in vaccine quality control, leading to significant evolution, especially since 1983 when the National Institute of Quality Control in Health (INCQS) centralized this control. INCQS conducts biological, microbiological, and physicochemical assays, such as pH, appearance, aluminum content, and thiomersal, the latter present in multidose vaccines as a preservative. Retrospective analysis of physicochemical assays reveals variations in analysis quantities, often correlated with specific vaccination campaigns. The introduction of new vaccines in the NIP, such as the pentavalent and inactivated polio vaccines, impacted quality control. Regarding the pH and appearance of vaccines, assays demonstrate improvements over time, including the adoption of more sensitive and specific techniques. The implementation of visual inspection aspect analysis as a preventive measure after occurrences of unsatisfactory lots underscores the commitment to vaccine safety. Public laboratories, like INCQS, play a crucial role in this process, ensuring the safety of immunobiological for the entire Brazilian population. The current challenge lies in the need to keep up with technological advancements to maintain vaccine quality.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422025000300313&lng=pt&tlng=ptvaccinealuminummercurypHappearance. |
| spellingShingle | Maria P. Blanco Cristiane Barata Silva Santos A. Vicentini Neto Lara M. Catarino Ozeias de Lima Leitão Elizabete P. Figuerêdo Mateus H. M. Neves Silvana C. Jacob Lisia M. G. dos Santos Importância dos ensaios físico-químicos no controle de qualidade de vacinas Química Nova vaccine aluminum mercury pH appearance. |
| title | Importância dos ensaios físico-químicos no controle de qualidade de vacinas |
| title_full | Importância dos ensaios físico-químicos no controle de qualidade de vacinas |
| title_fullStr | Importância dos ensaios físico-químicos no controle de qualidade de vacinas |
| title_full_unstemmed | Importância dos ensaios físico-químicos no controle de qualidade de vacinas |
| title_short | Importância dos ensaios físico-químicos no controle de qualidade de vacinas |
| title_sort | importancia dos ensaios fisico quimicos no controle de qualidade de vacinas |
| topic | vaccine aluminum mercury pH appearance. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422025000300313&lng=pt&tlng=pt |
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