Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation
Introduction. Transarterial chemoembolization is the first-line treatment in unresectable hepatocellular carcinoma. There is no standard treatment after transarterial chemoembolization failure. We report the case of a patient with advanced hepatocellular carcinoma who showed a complete response and...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2013/146215 |
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| author | Francesco Fiorica Carlo Greco Sergio Boccia Sergio Sartori Antonio Stefanelli Francesco Cartei Stefano Ursino |
| author_facet | Francesco Fiorica Carlo Greco Sergio Boccia Sergio Sartori Antonio Stefanelli Francesco Cartei Stefano Ursino |
| author_sort | Francesco Fiorica |
| collection | DOAJ |
| description | Introduction. Transarterial chemoembolization is the first-line treatment in unresectable hepatocellular carcinoma. There is no standard treatment after transarterial chemoembolization failure. We report the case of a patient with advanced hepatocellular carcinoma who showed a complete response and a long cancer control with hypofractionated stereotactic radiotherapy after transarterial chemoembolization failure. Case Presentation. A 70-year-old Caucasian woman was treated with transarterial chemoembolization for advanced hepatocellular, but no cancer control was obtained. A hypofractionated stereotactic radiotherapy was planned delivering 40 Gy in 5 fractions. A dramatic reduction in alpha-fetoprotein was observed. Contrast-enhanced ultrasonography at 1 and 2 months showed large necrotic areas. Computerised tomography scan showed a 90% objective tumour response, then a complete remission at 3 and 6 months after treatment, respectively. Status of patient remained unchanged for 2 years. Conclusions. Hypofractionated stereotactic radiotherapy can improve survival and prognosis of unresectable hepatocellular carcinoma patient. |
| format | Article |
| id | doaj-art-b2154262b7344eed841eb93da074157a |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-b2154262b7344eed841eb93da074157a2025-02-03T01:07:27ZengWileyCase Reports in Hepatology2090-65872090-65952013-01-01201310.1155/2013/146215146215Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case PresentationFrancesco Fiorica0Carlo Greco1Sergio Boccia2Sergio Sartori3Antonio Stefanelli4Francesco Cartei5Stefano Ursino6Department of Radiation Oncology, University Hospital “S. Anna,” Corso Giovecca 203, 44100 Ferrara, ItalyDepartment of Radiation Oncology, University Hospital “S. Chiara,” Via Roma 67, 56126 Pisa, ItalyDepartment of Gastroenterology, University Hospital “S. Anna,” Via Aldo Moro 8, 44124 Ferrara, ItalyDepartment of Internal Medicine, Section of Interventional Ultrasound, University Hospital “S. Anna,” Via Aldo Moro 8, 44124 Ferrara, ItalyDepartment of Radiation Oncology, University Hospital “S. Anna,” Corso Giovecca 203, 44100 Ferrara, ItalyDepartment of Radiation Oncology, University Hospital “S. Anna,” Corso Giovecca 203, 44100 Ferrara, ItalyDepartment of Radiation Oncology, University Hospital “S. Anna,” Corso Giovecca 203, 44100 Ferrara, ItalyIntroduction. Transarterial chemoembolization is the first-line treatment in unresectable hepatocellular carcinoma. There is no standard treatment after transarterial chemoembolization failure. We report the case of a patient with advanced hepatocellular carcinoma who showed a complete response and a long cancer control with hypofractionated stereotactic radiotherapy after transarterial chemoembolization failure. Case Presentation. A 70-year-old Caucasian woman was treated with transarterial chemoembolization for advanced hepatocellular, but no cancer control was obtained. A hypofractionated stereotactic radiotherapy was planned delivering 40 Gy in 5 fractions. A dramatic reduction in alpha-fetoprotein was observed. Contrast-enhanced ultrasonography at 1 and 2 months showed large necrotic areas. Computerised tomography scan showed a 90% objective tumour response, then a complete remission at 3 and 6 months after treatment, respectively. Status of patient remained unchanged for 2 years. Conclusions. Hypofractionated stereotactic radiotherapy can improve survival and prognosis of unresectable hepatocellular carcinoma patient.http://dx.doi.org/10.1155/2013/146215 |
| spellingShingle | Francesco Fiorica Carlo Greco Sergio Boccia Sergio Sartori Antonio Stefanelli Francesco Cartei Stefano Ursino Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation Case Reports in Hepatology |
| title | Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation |
| title_full | Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation |
| title_fullStr | Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation |
| title_full_unstemmed | Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation |
| title_short | Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation |
| title_sort | hypofractionated stereotactic radiotherapy after transarterial chemoembolisation failure in an unresectable hepatocellular carcinoma a case presentation |
| url | http://dx.doi.org/10.1155/2013/146215 |
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