Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo
Abstract Early‐stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize f...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409361 |
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| author | Jiwoong Kim Joo Young Kweon Seongwook Choi Hyunseo Jeon Minsik Sung Rongkang Gao Chengbo Liu Chulhong Kim Yong Joo Ahn |
| author_facet | Jiwoong Kim Joo Young Kweon Seongwook Choi Hyunseo Jeon Minsik Sung Rongkang Gao Chengbo Liu Chulhong Kim Yong Joo Ahn |
| author_sort | Jiwoong Kim |
| collection | DOAJ |
| description | Abstract Early‐stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize further treatment strategies, and improve the prognosis. Photoacoustic computed tomography (PACT), a non‐invasive imaging modality that captures multiparametric high‐resolution images of vessel structures, is well suited for evaluating cerebrovascular structures and their function. Here 3D multiparametric transcranial PACT is implemented to monitor the early stage of a photothrombotic (PT)‐stroke model in living rats. New vessels in the PT‐induced region are successfully observed using PACT, and these observations are confirmed by histology. Then, using multiparametric PACT, it is found that the SO2 in the ischemic area decreases while the SO2 in newly formed vessels increases, and the SO2 in the PT region also recovers. These findings demonstrate PACT's remarkable ability to image and monitor cerebrovascular morphologic and physiological changes. They highlight the usefulness of whole‐brain PACT as a potentially powerful tool for early diagnosis and therapeutic decision‐making in treating ischemic stroke. |
| format | Article |
| id | doaj-art-b2153f4a700f4cf38c65fd892f83271e |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-b2153f4a700f4cf38c65fd892f83271e2025-01-29T09:50:19ZengWileyAdvanced Science2198-38442025-01-01124n/an/a10.1002/advs.202409361Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In VivoJiwoong Kim0Joo Young Kweon1Seongwook Choi2Hyunseo Jeon3Minsik Sung4Rongkang Gao5Chengbo Liu6Chulhong Kim7Yong Joo Ahn8Departments of Convergence IT Engineering Medical Science and Engineering Electrical Engineering and Mechanical Engineering Pohang University of Science and Technology (POSTECH) Cheongam‐ro 77, Nam‐gu Pohang Gyeongbuk 37673 Republic of KoreaDepartments of Convergence IT Engineering Medical Science and Engineering Electrical Engineering and Mechanical Engineering Pohang University of Science and Technology (POSTECH) Cheongam‐ro 77, Nam‐gu Pohang Gyeongbuk 37673 Republic of KoreaDepartments of Convergence IT Engineering Medical Science and Engineering Electrical Engineering and Mechanical Engineering Pohang University of Science and Technology (POSTECH) Cheongam‐ro 77, Nam‐gu Pohang Gyeongbuk 37673 Republic of KoreaDepartments of Convergence IT Engineering Medical Science and Engineering Electrical Engineering and Mechanical Engineering Pohang University of Science and Technology (POSTECH) Cheongam‐ro 77, Nam‐gu Pohang Gyeongbuk 37673 Republic of KoreaDepartments of Convergence IT Engineering Medical Science and Engineering Electrical Engineering and Mechanical Engineering Pohang University of Science and Technology (POSTECH) Cheongam‐ro 77, Nam‐gu Pohang Gyeongbuk 37673 Republic of KoreaResearch Center for Biomedical Optics and Molecular Imaging Key Laboratory of Biomedical Imaging Science and Systems Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaResearch Center for Biomedical Optics and Molecular Imaging Key Laboratory of Biomedical Imaging Science and Systems Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 ChinaDepartments of Convergence IT Engineering Medical Science and Engineering Electrical Engineering and Mechanical Engineering Pohang University of Science and Technology (POSTECH) Cheongam‐ro 77, Nam‐gu Pohang Gyeongbuk 37673 Republic of KoreaDepartments of Convergence IT Engineering Medical Science and Engineering Electrical Engineering and Mechanical Engineering Pohang University of Science and Technology (POSTECH) Cheongam‐ro 77, Nam‐gu Pohang Gyeongbuk 37673 Republic of KoreaAbstract Early‐stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize further treatment strategies, and improve the prognosis. Photoacoustic computed tomography (PACT), a non‐invasive imaging modality that captures multiparametric high‐resolution images of vessel structures, is well suited for evaluating cerebrovascular structures and their function. Here 3D multiparametric transcranial PACT is implemented to monitor the early stage of a photothrombotic (PT)‐stroke model in living rats. New vessels in the PT‐induced region are successfully observed using PACT, and these observations are confirmed by histology. Then, using multiparametric PACT, it is found that the SO2 in the ischemic area decreases while the SO2 in newly formed vessels increases, and the SO2 in the PT region also recovers. These findings demonstrate PACT's remarkable ability to image and monitor cerebrovascular morphologic and physiological changes. They highlight the usefulness of whole‐brain PACT as a potentially powerful tool for early diagnosis and therapeutic decision‐making in treating ischemic stroke.https://doi.org/10.1002/advs.202409361brain imagingischemic strokemultiparametric imagingphotoacoustic imaging |
| spellingShingle | Jiwoong Kim Joo Young Kweon Seongwook Choi Hyunseo Jeon Minsik Sung Rongkang Gao Chengbo Liu Chulhong Kim Yong Joo Ahn Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo Advanced Science brain imaging ischemic stroke multiparametric imaging photoacoustic imaging |
| title | Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo |
| title_full | Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo |
| title_fullStr | Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo |
| title_full_unstemmed | Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo |
| title_short | Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo |
| title_sort | non invasive photoacoustic cerebrovascular monitoring of early stage ischemic strokes in vivo |
| topic | brain imaging ischemic stroke multiparametric imaging photoacoustic imaging |
| url | https://doi.org/10.1002/advs.202409361 |
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