Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus

Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus

Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. For the attaching and effacing (A/E) bacterial family member and murine pathogen Citrobacter rodentiu...

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Bibliographic Details
Main Authors: Yan Chen, Ashley Gilliland, Qiaochu Liang, Xiao Han, Hyungjun Yang, Jocelyn Chan, Dominique Lévesque, Kyung-Mee Moon, Parandis Daneshgar, François-Michel Boisvert, Leonard Foster, Wesley F. Zandberg, Kirk Bergstrom, Hong B. Yu, Bruce A. Vallance
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Enteric pathogens
EspC
air-liquid interface
colonoids
mucus
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2494717
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