A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review
Background. Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a cl...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/953714 |
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| _version_ | 1832556212661518336 |
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| author | Mian Bilal Alam Amin Kadoura Magesh Sathaiah |
| author_facet | Mian Bilal Alam Amin Kadoura Magesh Sathaiah |
| author_sort | Mian Bilal Alam |
| collection | DOAJ |
| description | Background. Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a class of drugs, are the most common cause of DIH. Here, we present a fatal case of nafcillin-induced hepatotoxicity confirmed by liver biopsy, with total bilirubin peaking to 21.8 mg/dl and subsequent further extensive evaluation for hepatic injury turning out to be negative. |
| format | Article |
| id | doaj-art-b207ba5e4b8e4cf7b45fac1e9d04ee58 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-b207ba5e4b8e4cf7b45fac1e9d04ee582025-02-03T05:46:08ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/953714953714A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature ReviewMian Bilal Alam0Amin Kadoura1Magesh Sathaiah2Department of Internal Medicine, Conemaugh Memorial Medical Center Hospital, Johnstown, PA 15905, USADepartment of Internal Medicine, Conemaugh Memorial Medical Center Hospital, Johnstown, PA 15905, USADepartment of Surgery, University of Pittsburgh School of Medicine, and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USABackground. Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a class of drugs, are the most common cause of DIH. Here, we present a fatal case of nafcillin-induced hepatotoxicity confirmed by liver biopsy, with total bilirubin peaking to 21.8 mg/dl and subsequent further extensive evaluation for hepatic injury turning out to be negative.http://dx.doi.org/10.1155/2012/953714 |
| spellingShingle | Mian Bilal Alam Amin Kadoura Magesh Sathaiah A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review Case Reports in Medicine |
| title | A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review |
| title_full | A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review |
| title_fullStr | A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review |
| title_full_unstemmed | A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review |
| title_short | A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review |
| title_sort | fatal case of nafcillin induced hepatotoxicity a case report and the literature review |
| url | http://dx.doi.org/10.1155/2012/953714 |
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