Engineering functionally-optimized aptamers against SARS-Cov-2 for blocking spike-ACE2 interaction and aptasensor detection

Engineering functionally-optimized aptamers against SARS-Cov-2 for blocking spike-ACE2 interaction and aptasensor detection

Both the limited research about structure-function relationship and the ill-defined process of conformational dynamic change greatly impede the development of aptamer engineering transformation and seriously restrict the practical applications of aptamers. In this work, an optimization strategy comb...

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Bibliographic Details
Main Authors: Xiangdong Lai, Weiwei Zhao, Lihua Jiang, Jing Li, Muhammad Faizan Munawer, Jiejuan Lai, Jesus Alejandro Martinez Juarez, Miraj Ud din, Xiaoyang Zhang, Zhongquan Song, Tao Wu, Yiyue Ge, Hui Jiang, Xiaohui Liu, Xuemei Wang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Aptamer optimization
Exonuclease III digestion
In silico simulation
SARS-CoV-2 spike
Aptasensors
Inactivated virus detection
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425005903
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